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Reversal of Antiparkinsonian Drug Toxicity by Physostigmine: A Controlled Study
- Source :
- American Journal of Psychiatry. 130:141-145
- Publication Year :
- 1973
- Publisher :
- American Psychiatric Association Publishing, 1973.
-
Abstract
- Three female schizophrenic patients receiving a combination of psychotropic agents, including the antiparkinsonian agent benztropine mesylate, developed the central anticholinergic syndrome, consisting of hallucinations, anxiety, short-term memory loss, disorientation, and agitation. These symptoms responded dramatically to physostigmine salicylate administered intramuscularly; they were unaffected by placebo injection given on a double-blind basis. In patients receiving multiple psychotropic drugs, evaluation of whether the patient is acting confused because of the combined central anticholinergic properties of these drugs is important. When identified, this syndrome can usually be treated by reduction of the dose of the anticholinergic agents or in special instances by the use of the cholinomimetic agent physostigmine.
- Subjects :
- Adult
Physostigmine
Adolescent
Hallucinations
medicine.drug_class
Anticholinergic agents
Anxiety
Placebo
Injections, Intramuscular
Psychoses, Substance-Induced
Antiparkinson Agents
Placebos
Phenothiazines
Anticholinergic
medicine
Humans
Benztropine
Antiparkinsonian Agent
Antidepressive Agents
Psychiatry and Mental health
Anesthesia
Toxicity
Schizophrenia
Benztropine Mesylate
Female
Amnesia
Psychology
Psychotropic Agent
Antipsychotic Agents
Tropanes
medicine.drug
Subjects
Details
- ISSN :
- 15357228 and 0002953X
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- American Journal of Psychiatry
- Accession number :
- edsair.doi.dedup.....d040dfbac2a487131fc3f24668d2ceb8