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An enzyme-responsive membrane for antibiotic drug release and local periodontal treatment
- Source :
- Colloids and Surfaces B: Biointerfaces. 183:110454
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Periodontitis is a chronic, destructive inflammatory disease that injures tooth- supporting tissues, eventually leading to tooth loss. Complete eradication of periodontal pathogenic microorganisms is fundamental to allow periodontal healing and commonly precedes periodontal tissue regeneration. To address this challenge, we report a strategy for developing an enzyme-mediated periodontal membrane for targeted antibiotic delivery into infectious periodontal pockets; the unique components of the membrane will also benefit periodontal alveolar bone repair. In this approach, a chitosan membrane containing polyphosphoester and minocycline hydrochloride (PPEM) was prepared. Physical, morphological, and ultrastructural analyses were carried out in order to assess cellular compatibility, drug release and antibacterial activity in vitro. Additionally, the functionality of the PPEM membrane was evaluated in vivo with a periodontal defect model in rats. The results confirm that the PPEM membrane exhibits good physical properties with excellent antibacterial activity and successfully promotes periodontal tissue repair, making it promising for periodontal treatment.
- Subjects :
- Male
Bone Regeneration
Gingival and periodontal pocket
Cell Survival
Gingiva
Minocycline
02 engineering and technology
Pharmacology
01 natural sciences
Rats, Sprague-Dawley
Colloid and Surface Chemistry
In vivo
0103 physical sciences
medicine
Tooth loss
Animals
Humans
Physical and Theoretical Chemistry
Periodontitis
Cells, Cultured
Dental alveolus
Chitosan
Osteoblasts
010304 chemical physics
business.industry
Regeneration (biology)
Minocycline Hydrochloride
Membranes, Artificial
Surfaces and Interfaces
General Medicine
Fibroblasts
021001 nanoscience & nanotechnology
medicine.disease
In vitro
Anti-Bacterial Agents
Enzymes
Drug Liberation
medicine.symptom
0210 nano-technology
business
Biotechnology
Subjects
Details
- ISSN :
- 09277765
- Volume :
- 183
- Database :
- OpenAIRE
- Journal :
- Colloids and Surfaces B: Biointerfaces
- Accession number :
- edsair.doi.dedup.....d0426fa56bd216d1468a97043930ed41