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Production of functional cardiomyocytes and cardiac tissue from human induced pluripotent stem cells for regenerative therapy
- Source :
- Journal of Molecular and Cellular Cardiology. 164:83-91
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- The emergence of human induced pluripotent stem cells (hiPSCs) has revealed the potential for curing end-stage heart failure. Indeed, transplantation of hiPSC-derived cardiomyocytes (hiPSC-CMs) may have applications as a replacement for heart transplantation and conventional regenerative therapies. However, there are several challenges that still must be overcome for clinical applications, including large-scale production of hiPSCs and hiPSC-CMs, elimination of residual hiPSCs, purification of hiPSC-CMs, maturation of hiPSC-CMs, efficient engraftment of transplanted hiPSC-CMs, development of an injection device, and avoidance of post-transplant arrhythmia and immunological rejection. Thus, we developed several technologies based on understanding of the metabolic profiles of hiPSCs and hiPSC derivatives. In this review, we outline how to overcome these hurdles to realize the transplantation of hiPSC-CMs in patients with heart failure and introduce cutting-edge findings and perspectives for future regenerative therapy.
- Subjects :
- Heart Failure
Heart transplantation
education.field_of_study
business.industry
medicine.medical_treatment
Lactate dehydrogenase A
Induced Pluripotent Stem Cells
Cell Differentiation
medicine.disease
Bioinformatics
Regenerative medicine
Embryonic stem cell
Transplantation
health services administration
Heart failure
Humans
Medicine
Myocytes, Cardiac
Human Induced Pluripotent Stem Cells
Cardiology and Cardiovascular Medicine
business
education
Induced pluripotent stem cell
Molecular Biology
health care economics and organizations
Subjects
Details
- ISSN :
- 00222828
- Volume :
- 164
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular and Cellular Cardiology
- Accession number :
- edsair.doi.dedup.....d05552cab3a8053fa7e95b8795926fc3