Supplementary Tables and Figures from Phase I Study of Single-Agent Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Patients with Advanced Cancer

Supplementary Table S1. Reason for treatment discontinuation Supplementary Table S2. Select laboratory abnormalities by maximum CTCAE grade Supplementary Table S3. Pharmacokinetic parameters for single-agent utomilumab (cycle 1) Supplementary Figure S1. Patient disposition. Supplementary Figure S2. Dose normalized Cmax of single-agent utomilumab in ADA-negative and ADA-positive patients (cycle 2, day 1). Supplementary Figure S3. Lymphocyte subpopulations assessed by flow cytometry over an 8-week (2-cycle) period following treatment with utomilumab.