Back to Search
Start Over
HLA Class II-DRB1 Alleles with Hepatitis C Virus Infection Outcome in Egypt: A Multicentre Family-based Study
HLA Class II-DRB1 Alleles with Hepatitis C Virus Infection Outcome in Egypt: A Multicentre Family-based Study
- Source :
- Annals of Hepatology, Vol 18, Iss 1, Pp 68-77 (2019)
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Introduction and aim. Hepatitis C virus (HCV) infection is a global medical problem. HLA –DRB1 alleles have an important role in immune response against HCV. The aim of this study is to clarify the contribution of HLA –DRB1 alleles in HCV susceptibility in a multicentre family-based study. Material and methods. A total of 162 Egyptian families were recruited in this study with a total of 951 individuals (255 with chronic hepatitis C (CHC), 588 persons in the control group(-ve household contact to HCV) and 108 persons who spontaneously cleared the virus (SVC). All subjects were genotyped for HLA -DRB1 alleles by SSP-PCR and sequence based typing (SBT) methods. Results. The carriage of alleles 3:01:01 and 13:01:01 were highly significant in CHC when compared to that of control and SVC groups [OR of 3 family = 5.1289, PC (Bonferroni correction ) = 0.0002 and 5.9847, PC = 0.0001 and OR of 13 family = 4.6860, PC = 0.0002 and OR = 6.5987, PC = 0.0001 respectively]. While DRB1*040501, DRB1*040101, DRB1*7:01:01 and DRB1*110101 alleles were more frequent in SVC group than CHC patients (OR = 0.4052, PC = 0.03, OR: OR = 0.0916, PC = 0.0006, OR = 0.1833, PC = 0.0006 and OR = 0.4061, PC = 0.0001 respectively). Conclusions. It was concluded that among the Egyptian families, HLA- DRB1*030101, and DRB1*130101 alleles associated with the risk of progression to CHC infection, while DRB1*040101, DRB1*040501, DRB1*7:01:01and DRB1*110101 act as protective alleles against HCV infection.
- Subjects :
- 0301 basic medicine
Hla class ii
Adult
Male
musculoskeletal diseases
Genotype
Hepatitis C virus
Specialties of internal medicine
Human leukocyte antigen
Hepacivirus
medicine.disease_cause
Virus
03 medical and health sciences
0302 clinical medicine
Immune system
Gene Frequency
HCV susceptibility
virus clearance
immune system diseases
medicine
Humans
Family
Genetic Predisposition to Disease
Allele
skin and connective tissue diseases
Alleles
Polymorphism, Genetic
Hepatology
business.industry
Incidence
General Medicine
Hepatitis C, Chronic
030104 developmental biology
Carriage
RC581-951
Immunology
DNA, Viral
intrafamilial
HLA-DRB1 polymorphism
030211 gastroenterology & hepatology
Egypt
Female
Family based
business
HLA-DRB1 Chains
Subjects
Details
- ISSN :
- 16652681
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Annals of Hepatology
- Accession number :
- edsair.doi.dedup.....d0b2385b802401465426cfc61106035e
- Full Text :
- https://doi.org/10.5604/01.3001.0012.2122