A common pathway for genetic events leading to pheochromocytoma

Authors :: Patrick H. Maxwell
Source :: Cancer Cell. 8:91-93
Publication Year :: 2005
Publisher :: Elsevier BV, 2005.
Abstract: SummaryMutations in VHL, RET, NF1, SDHB, SDHC, and SDHD can give rise to pheochromocytoma/paraganglioma. These different genetic lesions may all act by decreasing the activity of a 2-oxoglutarate-dependent oxygenase, SM-20/EglN3/PHD3, resulting in reduced apoptosis of neural crest cells during development.