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Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
- Source :
- Stem Cells International, Stem Cells International, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Hindawi Limited, 2021.
-
Abstract
- Ischemic stroke is a serious cerebral disease that often induces death and long-term disability. As a currently available therapy for recanalization after ischemic stroke, thrombolysis, including intravenous thrombolysis and endovascular therapy, still cannot be applicable to all patients due to the narrow time window. Mesenchymal stem cell (MSC) transplantation therapy, which can trigger neuronal regeneration and repair, has been considered as a significant advance in treatment of ischemic stroke. MSC transplantation therapy has exhibited its potential to improve the neurological function in ischemic stroke. Our review describes the current progress and future perspective of MSC transplantation therapy in ischemic stroke treatment, including cell types, transplantation approaches, therapeutic mechanisms, and preliminary clinical trials of MSC transplantation, for providing us an update role of MSC transplantation in ischemic stroke treatment.
- Subjects :
- medicine.medical_specialty
business.industry
medicine.medical_treatment
Mesenchymal stem cell
Neurological function
Review Article
Cell Biology
Thrombolysis
Disease
RC31-1245
Transplantation
Clinical trial
surgical procedures, operative
Time windows
Internal medicine
Ischemic stroke
medicine
Cardiology
cardiovascular diseases
business
Molecular Biology
Subjects
Details
- ISSN :
- 16879678 and 1687966X
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- Stem Cells International
- Accession number :
- edsair.doi.dedup.....d0ce569bbb1a0b27af00e7e8ce1b4b85