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Volumetric assessment of apparent diffusion coefficient predicts outcome following chemoradiation for cervical cancer
- Source :
- Radiother Oncol
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- OBJECTIVE: To determine the utility of volumetric diffusion weighted imaging (DWI) compared to other clinical factors for predicting recurrence and survival in cervical cancer patients treated with definitive chemoradiation. METHODS AND MATERIALS: We retrospectively studied cervical cancer patients treated with definitive chemoradiation between 2009–2013 at a single institution with a baseline MRI with DWI and 18F-FDG positron emission tomography/computed tomography (FDG-PET) scan. To identify clinical and imaging metrics correlated with survival and recurrence endpoints, variable importance values were calculated from random forest models. To provide clinically relevant threshold values, recursive partitioning analysis dichotomized patients into potential risk groups based on selected metrics. Cox’s proportional hazard models assessed the effect of clinical and imaging factors on survival endpoints. RESULTS: Ninety-three patients were included in the analysis (median age 50 years). At a median follow-up of 35.6 months, 32 patients (34%) had disease recurrence. In the best multivariate model including clinical and imaging parameters, 90(th) percentile ADC
- Subjects :
- Adult
Male
Percentile
medicine.medical_specialty
Uterine Cervical Neoplasms
Recursive partitioning
Disease-Free Survival
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Predictive Value of Tests
Positron Emission Tomography Computed Tomography
medicine
Humans
Effective diffusion coefficient
Radiology, Nuclear Medicine and imaging
Progression-free survival
Aged
Proportional Hazards Models
Retrospective Studies
Cervical cancer
medicine.diagnostic_test
business.industry
Chemoradiotherapy
Hematology
Middle Aged
Prognosis
medicine.disease
Primary tumor
Diffusion Magnetic Resonance Imaging
Oncology
Positron emission tomography
Positron-Emission Tomography
030220 oncology & carcinogenesis
Female
Radiology
Neoplasm Recurrence, Local
business
Diffusion MRI
Subjects
Details
- ISSN :
- 01678140
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- Radiotherapy and Oncology
- Accession number :
- edsair.doi.dedup.....d0d35a54eb1df4af6fb84e6c323d9ee6