High-Throughput Flow Cytometry

This article describes the creation of a discovery team in an academic environment. The team is specifically structured to perform four integrated activities: characterizing membrane protein, formatting the materials for analysis of cell physiology and molecular interactions, performing screens of small-molecule activity on a novel high-throughput flow cytometric instrument platform, and integrating virtual screening with activity screening. These activities improve the overall efficiency of the discovery process. Keywords: discovery team; virtual screening; cell physiology; molecular interactions