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Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson’s disease
- Source :
- Molecular Brain, Molecular Brain, Vol 14, Iss 1, Pp 1-17 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Parkinson’s disease (PD) is a multi-system neurodegenerative disorder. Patients with PD often suffer chronic pain. In the present study, we investigated motor, sensory and emotional changes in three different PD mice models. We found that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treatment caused significant changes in all measurements. Mechanical hypersensitivity of PD model induced by MPTP peaked at 3 days and persisted for at least 14 days. Using Fos transgenic mice, we found that neurons in the anterior cingulate cortex (ACC) were activated after MPTP treatment. Inhibiting ACC by bilateral microinjection of muscimol significantly reduced mechanical hypersensitivity and anxiety-like responses. By contrast, MPTP induced motor deficit was not affected, indicating ACC activity is mostly responsible for sensory and emotional changes. We also investigated excitatory synaptic transmission and plasticity using brain slices of MPTP treated animals. While L-LTP was blocked or significantly reduced. E-LTP was not significantly affected in slices of MPTP treated animals. LTD induced by repetitive stimulation was not affected. Furthermore, we found that paired-pulse facilitation and spontaneous release of glutamate were also altered in MPTP treated animals, suggesting presynaptic enhancement of excitatory transmission in PD. Our results suggest that ACC synaptic transmission is enhanced in the animal model of PD, and cortical excitation may play important roles in PD related pain and anxiety.
- Subjects :
- medicine.medical_specialty
Parkinson's disease
Chronic pain
Neurotransmission
Gyrus Cinguli
Synaptic Transmission
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Mice
Internal medicine
medicine
Animals
Humans
RC346-429
ACC
Molecular Biology
Anterior cingulate cortex
MPTP
Neurons
business.industry
Research
Glutamate receptor
Long-term potentiation
Parkinson Disease
medicine.disease
Mice, Inbred C57BL
Disease Models, Animal
Endocrinology
medicine.anatomical_structure
Muscimol
chemistry
nervous system
Excitatory postsynaptic potential
Parkinson’s disease
Neurology. Diseases of the nervous system
LTP
business
Subjects
Details
- Language :
- English
- ISSN :
- 17566606
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Molecular Brain
- Accession number :
- edsair.doi.dedup.....d0e09af28c71d590bd8a7742b798e5a4