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Use of Contrast-Enhanced Ultrasound in the Differential Diagnosis of Adrenal Tumors in Dogs
- Source :
- Journal of the American Animal Hospital Association. 52:132-143
- Publication Year :
- 2016
- Publisher :
- American Animal Hospital Association, 2016.
-
Abstract
- We evaluated the diagnostic accuracy of the contrast-enhanced ultrasonography (CEUS), using a second-generation microbubble contrast agent, in differentiating the different types of adrenal mass lesions in 24 dogs. At B-mode ultrasound, 9 lesions involved the right adrenal gland, 14 the left, and 1 was bilateral. Each dog received a bolus of the contrast agent into the cephalic vein, immediately followed by a 5-mL saline flush. The first contrast enhancement of each adrenal lesion was evaluated qualitatively to assess the degree of enhancement and its distribution during the wash-in and wash-out phases, as well as the presence of non-vascularized areas and specific vascular patterns. Pathological diagnoses were determined in all dogs by histopathology or by cytology. Combining enhancement degree and vascularity resulted in the best predictive model, allowing CEUS to differentiate adrenocortical adenoma (n=10), adenocarcinoma (n=7), and pheochromocytoma (n=7) with an accuracy of 91.7% (P < 0.001). Combining enhancement degree and vascularity, CEUS can discriminate malignant versus benign adrenal lesions with a sensitivity of 100.0%, a specificity of 80.0%, and an accuracy of 91.7% (P < 0.001). In conclusion, results of this study confirm that CEUS is useful for differentiating between the different types of adrenal tumors in dogs.
- Subjects :
- medicine.medical_specialty
040301 veterinary sciences
Adrenal Gland Neoplasm
Adrenal Gland Neoplasms
Contrast Media
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
Adrenocortical adenoma
Diagnosis, Differential
0403 veterinary science
Pheochromocytoma
03 medical and health sciences
Dogs
0302 clinical medicine
Vascularity
medicine
Animals
Dog Diseases
Small Animals
Ultrasonography
business.industry
Ultrasound
04 agricultural and veterinary sciences
medicine.disease
Adenocarcinoma
Histopathology
Radiology
medicine.symptom
business
Contrast-enhanced ultrasound
Subjects
Details
- ISSN :
- 15473317 and 05872871
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Journal of the American Animal Hospital Association
- Accession number :
- edsair.doi.dedup.....d0e676a428cd86e80bd1ede058e27a20