Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2

[Background]: MAP3K8 (Cot/tpl2) activates MKK1/2-Erk1/2 upon stimulation of receptors from the Toll-like/interleukin-1 receptor superfamily. [Results]: Cot/tpl2 plays an essential role in acetaminophen-induced liver injury by modulating the generation of inflammatory signals induced by necrotic cells. [Conclusion]: Sterile inflammatory processes triggered by tissue damage are modulated by Cot/tpl2. [Significance]: Cot/tpl2 contributes to the development of pathologies associated with inflammation triggered by damage-associated molecular patterns.
This work was supported by Grants SAF 2011-24481 (to S. A.) and SAF 2012-33283 (to A. M. V.) from MINECO (Spain) Comunidad de Madrid S2010/BMD-2423, EFSD/Amylin Programme 2011 (to A. M. V.) and a grant from the Mutua Madrileña (to S. A.).