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Top–Down Inhibitory Mechanisms Underlying Auditory–Motor Integration for Voice Control: Evidence by TMS
- Source :
- Cerebral Cortex. 30:4515-4527
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- The dorsolateral prefrontal cortex (DLPFC) has been implicated in auditory–motor integration for accurate control of vocal production, but its precise role in this feedback-based process remains largely unknown. To this end, the present event-related potential study applied a transcranial magnetic stimulation (TMS) protocol, continuous theta-burst stimulation (c-TBS), to disrupt cortical activity in the left DLPFC as young adults vocalized vowel sounds while hearing their voice unexpectedly shifted upwards in pitch. The results showed that, as compared to the sham condition, c-TBS over left DLPFC led to significantly larger vocal compensations for pitch perturbations that were accompanied by significantly smaller cortical P2 responses. Source localization analyses revealed that this brain activity pattern was the result of reduced activation in the left superior frontal gyrus and right inferior parietal lobule (supramarginal gyrus). These findings demonstrate c-TBS-induced modulatory effects of DLPFC on the neurobehavioral processing of vocal pitch regulation, suggesting that disrupting prefrontal function may impair top–down inhibitory control mechanisms that prevent speech production from being excessively influenced by auditory feedback, resulting in enhanced vocal compensations for feedback perturbations. This is the first study that provides direct evidence for a causal role of the left DLPFC in auditory feedback control of vocal production.
- Subjects :
- Male
Speech production
Brain activity and meditation
Cognitive Neuroscience
medicine.medical_treatment
Prefrontal Cortex
Stimulation
Inhibitory postsynaptic potential
Young Adult
Cellular and Molecular Neuroscience
Supramarginal gyrus
Feedback, Sensory
otorhinolaryngologic diseases
medicine
Humans
Speech
Attention
Pitch Perception
Auditory feedback
Transcranial Magnetic Stimulation
Transcranial magnetic stimulation
Dorsolateral prefrontal cortex
medicine.anatomical_structure
Female
Psychology
Neuroscience
psychological phenomena and processes
Subjects
Details
- ISSN :
- 14602199 and 10473211
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Cerebral Cortex
- Accession number :
- edsair.doi.dedup.....d0eac228b5999252bf27cb7fa72b1700