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Associations among echocardiography, cardiac biomarkers, insulin metabolism, morphology, and inflammation in cats with asymptomatic hypertrophic cardiomyopathy
- Source :
- Article, Hoek, I V, Hodgkiss-Geere, H, Bode, L, Hamilton-Elliot, J, Mõtsküla, P, Palermo, V, Martinez-Pereira, Y, Culshaw, G, Ivanova, A & Dukes-McEwan, J 2020, ' Associations among echocardiography, cardiac biomarkers, insulin metabolism, morphology, and inflammation in cats with asymptomatic hypertrophic cardiomyopathy. ', Journal of Veterinary Internal Medicine . https://doi.org/10.1111/jvim.15730, JOURNAL OF VETERINARY INTERNAL MEDICINE, Journal of Veterinary Internal Medicine, Journal of Veterinary Internal Medicine, Vol 34, Iss 2, Pp 591-599 (2020)
- Publication Year :
- 2020
- Publisher :
- WILEY, 2020.
-
Abstract
- Background Insulin, insulin-like growth factor-1 (IGF-1), and inflammation possibly are involved in cats with asymptomatic hypertrophic cardiomyopathy (aHCM). Objectives To evaluate echocardiography, morphology, cardiac and inflammatory markers, insulin and IGF-1 in cats with aHCM. Animals Fifty-one client-owned cats with aHCM. Methods Observational descriptive study. Variables (body weight [BW], body condition score [BCS], echocardiography, and serum concentrations of N-terminal pro-B-type natriuretic peptide [NT-proBNP], ultra-sensitive troponin-I [c-TnI], serum amyloid A [SAA], insulin, glucose and IGF-1) were evaluated for significant increases above echocardiography cutoff values and laboratory reference ranges, associations and effect of left atrial (LA) remodeling and generalized hypertrophy. Results Cats with aHCM had BCS >= 6/9 (P = .01) and insulin (P < .001), NT-proBNP (P = .001) and cTn-I (P < .001) above laboratory reference ranges. Associations were present between NT-proBNP and maximum end-diastolic interventricular septum thickness (IVSd; rho = .32; P = .05), maximum end-diastolic left ventricular free wall thickness;(rho = .41; P = .01), LA/Aorta (rho = .52; P = .001) and LA diameter (LA-max; rho = .32; P = .05); c-TnI and LA/Aorta (rho = .49; P = .003) and LA-max (rho = .28; P = .05); and SAA and number of IVSd regions >= 6 mm thickness (rho = .28; P = .05). Body weight and BCS were associated with IGF-1 (r = 0.44; P = .001), and insulin (rho = .33; P = .02), glucose (rho = .29; P = .04) and IGF-1 (rho = .32; P = .02), respectively. Concentrations of NT-proBNP (P = .02) and c-TnI (P = .01), and SAA (P = .02), were higher in cats with LA remodeling, and generalized hypertrophy, respectively. Conclusions and clinical importance Results suggest potential implications of insulin, IGF-1, and inflammation in cats with aHCM, but it remains to be confirmed whether these findings represent a physiological process or a part of the pathogenesis and development of disease. Royal Canin SAS van Hoek, I (reprint author), Royal Canin SAS, Res & Dev, 650 Ave Petite Camargue, F-30470 Aimargues, France. ingrid.van.hoek@royalcanin.com
- Subjects :
- Male
medicine.medical_specialty
insulin/IGF‐1 mediated growth
insulin
insulin/IGF-1 mediated growth
040301 veterinary sciences
medicine.drug_class
medicine.medical_treatment
Cardiology
cat
Standard Article
030204 cardiovascular system & hematology
Cat Diseases
Asymptomatic
Muscle hypertrophy
0403 veterinary science
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Natriuretic peptide
hypertrophic obstructive cardiomyopathy
Animals
Humans
IGF-1 mediated growth
Serum amyloid A
CATS
lcsh:Veterinary medicine
General Veterinary
biology
business.industry
Insulin
cardiac hypertrophy
Hypertrophic cardiomyopathy
04 agricultural and veterinary sciences
Cardiomyopathy, Hypertrophic
medicine.disease
Troponin
Standard Articles
Echocardiography
biology.protein
Cats
lcsh:SF600-1100
Female
SMALL ANIMAL
medicine.symptom
business
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Article, Hoek, I V, Hodgkiss-Geere, H, Bode, L, Hamilton-Elliot, J, Mõtsküla, P, Palermo, V, Martinez-Pereira, Y, Culshaw, G, Ivanova, A & Dukes-McEwan, J 2020, ' Associations among echocardiography, cardiac biomarkers, insulin metabolism, morphology, and inflammation in cats with asymptomatic hypertrophic cardiomyopathy. ', Journal of Veterinary Internal Medicine . https://doi.org/10.1111/jvim.15730, JOURNAL OF VETERINARY INTERNAL MEDICINE, Journal of Veterinary Internal Medicine, Journal of Veterinary Internal Medicine, Vol 34, Iss 2, Pp 591-599 (2020)
- Accession number :
- edsair.doi.dedup.....d0ef519c005b21af6441331ef637bc59