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Silibinin alleviates hyperlipidaemia, restores mucin content, modulates TGF-β and fosters apoptosis in experimental rat colon carcinogenesis
- Source :
- Journal of Functional Foods, Vol 11, Iss, Pp 472-481 (2014)
- Publication Year :
- 2014
- Publisher :
- Elsevier, 2014.
-
Abstract
- The effect of silibinin on lipid profile, colonic mucin content, transforming growth factor beta (TGF-β) expression, cell proliferation and apoptosis in high fat diet fed rats challenged with 1, 2 dimethyl hydrazine (DMH) was investigated. Rats were randomized into six groups. Group 1: Control rats; Group 2: Silibinin (50 mg/kg of b.w. p.o every day); Group 3: DMH (20 mg/kg b.w.); Groups 4–6: DMH + Silibinin (Initiation, Post-initiation and entire period treatment regimens, respectively). At the end of 32nd week, DMH alone administered rats showed hyperlipidaemia and colon tumour burden with decreased mucin content. The expression of TGF-β was found to be lost in the early adenoma but increased stromal positivity of TGF-β was observed in adenocarcinoma of the colon. Evasion of apoptosis is also seen in the colon of tumour bearing rats. These DMH induced pathological changes were attenuated by silibinin supplementation reflecting its antihyperlipidaemic, colon protective and anticarcinogenic effects.
- Subjects :
- medicine.medical_specialty
endocrine system
Colorectal cancer
Medicine (miscellaneous)
Silibinin
chemistry.chemical_compound
Internal medicine
medicine
TX341-641
Nutrition and Dietetics
Bax/Bcl2 ratio
biology
Cell growth
Nutrition. Foods and food supply
Mucin
Transforming growth factor beta
medicine.disease
Colon cancer
Lipid profile
AgNOR
Endocrinology
Biochemistry
chemistry
Apoptosis
Caspases
biology.protein
Adenocarcinoma
Food Science
Transforming growth factor
Subjects
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....d0f76b3f579260692c2050fa31f9a8b6