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Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women
- Source :
- Molecular nutritionfood research. 61(3)
- Publication Year :
- 2016
-
Abstract
- SCOPE: What effect does replacing chicken or pork with herring as the main dietary source of protein have on the human plasma metabolome? METHOD AND RESULTS: A randomised crossover trial with 15 healthy obese men and women (age 24-70 years). Subjects were randomly assigned to four weeks of herring diet or a reference diet of chicken and lean pork, five meals per week, followed by a washout and the other intervention arm. Fasting blood serum metabolites were analysed at 0, 2 and 4 weeks for eleven subjects with available samples, using GC-MS based metabolomics. The herring diet decreased plasma citrate, fumarate, isocitrate, glycolate, oxalate, agmatine and methyhistidine and increased asparagine, ornithine, glutamine and the hexosamine glucosamine. Modelling found that the tricarboxylic acid cycle, glyoxylate, and arginine metabolism were affected by the intervention. The effect on arginine metabolism was supported by an increase in blood nitric oxide in males on the herring diet. CONCLUSION: The results suggest that eating herring instead of chicken and lean pork leads to important metabolic effects, particularly on energy and amino acid metabolism. Our findings support the hypothesis that there are metabolic effects of herring intake unrelated to the long chain n-3 polyunsaturated fatty acid content.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Arginine
Biology
Nitric Oxide
03 medical and health sciences
chemistry.chemical_compound
Herring
Blood serum
Internal medicine
Fish Products
medicine
Metabolome
Animals
Humans
Obesity
Amino Acids
Aged
chemistry.chemical_classification
Tricarboxylic Acids
Ornithine
Middle Aged
Overweight
Crossover study
Diet
Glutamine
Red Meat
030104 developmental biology
Endocrinology
chemistry
Female
Chickens
Food Science
Biotechnology
Polyunsaturated fatty acid
Subjects
Details
- ISSN :
- 16134133
- Volume :
- 61
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Molecular nutritionfood research
- Accession number :
- edsair.doi.dedup.....d0f84804d739d57ff975ef68e922dc07