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Atosiban and Pregnancy Outcomes Following In Vitro Fertilization Treatment for Infertile Women Requiring One, Two, or More Embryo Transfer Cycles: A Longitudinal Cohort Study
- Source :
- Reproductive Sciences. 27:853-859
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- We assessed the effect of atosiban on pregnancy outcomes following in vitro fertilization (IVF) treatment among infertile women requiring different numbers of embryo transfer (ET) cycles (i.e., one, two, and more than two ET cycles). A longitudinal cohort study was conducted by utilizing the data from the Assisted Reproductive Technology Center in a university tertiary hospital during 2007-2017. Patients receiving IVF treatment with at least one ET cycle were included. Pregnancy outcomes following IVF treatment, including biochemical, clinical, and ongoing pregnancies, were investigated. The association between atosiban and IVF pregnancy was assessed using logistic generalized estimating equation models, with adjustment for time-varying clinical characteristics (e.g., maternal age) across multiple ET cycles for an individual. 403 women with 838 ET cycles were included, where 165 patients required one ET cycle, 133 patients required two ET cycles (a total of 266 ET cycles), and 105 patients required more than two ET cycles (a total of 407 ET cycles). Atosiban use was not significantly associated with pregnancy outcomes among all study infertile women undergoing IVF treatment. However, the results for women requiring more than two ET cycles showed significantly increased pregnancy rates associated with atosiban use (i.e., odds ratios [95% confidence interval] of 4.40 [1.52, 12.73] and 2.85 [1.45, 5.60] for clinical and ongoing pregnancies, respectively). This association was not observed for the women requiring only one or two ET cycles. Atosiban is a potential treatment for enhancing IVF pregnancy, especially among infertile women requiring more than two ET cycles.
- Subjects :
- Adult
0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
Reproductive medicine
Fertilization in Vitro
03 medical and health sciences
Hormone Antagonists
Vasotocin
0302 clinical medicine
Pregnancy
medicine
Humans
Longitudinal Studies
030219 obstetrics & reproductive medicine
In vitro fertilisation
Assisted reproductive technology
Obstetrics
business.industry
Pregnancy Outcome
Obstetrics and Gynecology
Atosiban
Odds ratio
Embryo Transfer
medicine.disease
Confidence interval
Embryo transfer
Treatment Outcome
030104 developmental biology
Female
business
Infertility, Female
medicine.drug
Subjects
Details
- ISSN :
- 19337205 and 19337191
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Reproductive Sciences
- Accession number :
- edsair.doi.dedup.....d1187a49df4a641dcc6ca01bfb416d0a