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Randomized crossover pharmacokinetic evaluation of subcutaneous versus intravenous granisetron in cancer patients treated with platinum-based chemotherapy
Randomized crossover pharmacokinetic evaluation of subcutaneous versus intravenous granisetron in cancer patients treated with platinum-based chemotherapy
- Source :
- The oncologist. 12(9)
- Publication Year :
- 2007
-
Abstract
- Background. 5-HT3-receptor antagonists are one of the mainstays of antiemetic treatment, and they are administered either i.v. or orally. Nevertheless, sometimes neither administration route is feasible, such as in patients unable to admit oral intake managed in an outpatient setting. Our objective was to evaluate the bioavailability of s.c. granisetron. Patients and Methods. Patients receiving platinum-based chemotherapy were randomized to receive 3 mg of granisetron either s.c. or i.v. in a crossover manner during two cycles. Blood and urine samples were collected after each cycle. Pharmacokinetic parameters observed with each administration route were compared by analysis of variance. Results. From May to November 2005, 31 patients were included and 25 were evaluable. Subcutaneous granisetron resulted in a 27% higher area under the concentration–time curve for 0–12 hours (AUC0–12h) and higher levels at 12 hours, with similar values for AUC0–24h. The maximum concentration was lower with the s.c. than with the i.v. route and was observed 30 minutes following s.c. administration. Conclusion. Granisetron administered s.c. achieves complete bioavailability. This is the first study that shows that s.c. granisetron might be a valid alternative to i.v. delivery. Further trials to confirm clinical equivalence are warranted. This new route of administration might be especially relevant for outpatient management of emesis in cancer patients.
- Subjects :
- Male
Cancer Research
Lung Neoplasms
Time Factors
medicine.drug_class
Vomiting
medicine.medical_treatment
Injections, Subcutaneous
Administration, Oral
Biological Availability
Antineoplastic Agents
Platinum Compounds
Granisetron
law.invention
Route of administration
Randomized controlled trial
Pharmacokinetics
law
Carcinoma, Non-Small-Cell Lung
Medicine
Antiemetic
Humans
Chemotherapy
Cross-Over Studies
business.industry
Middle Aged
Crossover study
Bioavailability
Oncology
Anesthesia
Area Under Curve
Injections, Intravenous
Antiemetics
Female
business
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 10837159
- Volume :
- 12
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- The oncologist
- Accession number :
- edsair.doi.dedup.....d123b6335a72806f1aecd7b7da5caa0e