Back to Search
Start Over
Immune-related adverse events and kidney function decline in patients with genitourinary cancers treated with immune checkpoint inhibitors
- Source :
- European Journal of Cancer. 157:50-58
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background In patients with genitourinary cancers, the effect of immune checkpoint inhibitors (ICIs) on kidney function is unknown. Patients and methods This is a retrospective cohort study of patients with renal cell carcinoma (RCC) and urothelial carcinoma who received ICIs at two major cancer centers between 2012 and 2018. Cumulative incidence and Fine and Gray subdistribution hazard models were performed to determine predictors of the co-primary outcomes, (1) acute kidney injury (AKI) and (2) sustained estimated glomerular filtration rate (eGFR) loss, defined as a >20% decline in eGFR sustained ≥90 days. We also determined the association between immune-related adverse events (irAE) and adverse kidney outcomes among patients surviving ≥1 year. Results 637 patients were included; 320 (50%) patients had RCC and 317 (50%) patients had urothelial carcinoma. Half of the cohort had eGFR Conclusion AKI and sustained eGFR loss are common in patients with genitourinary cancers receiving ICIs. irAEs may be a novel risk factor for kidney function decline among patients receiving ICIs.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Renal function
Renal cell carcinoma
Internal medicine
medicine
Humans
Cumulative incidence
Adverse effect
Carcinoma, Renal Cell
Immune Checkpoint Inhibitors
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Acute kidney injury
Cancer
Retrospective cohort study
Acute Kidney Injury
Middle Aged
medicine.disease
Kidney Neoplasms
Urinary Bladder Neoplasms
Cohort
Female
business
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 09598049
- Volume :
- 157
- Database :
- OpenAIRE
- Journal :
- European Journal of Cancer
- Accession number :
- edsair.doi.dedup.....d132ad8ecb60264419c2c2046cf17c69