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Effects of a Low-Carbohydrate Dietary Intervention on Hemoglobin A1c

Authors :
Kirsten S, Dorans
Lydia A, Bazzano
Lu, Qi
Hua, He
Jing, Chen
Lawrence J, Appel
Chung-Shiuan, Chen
Ming-Hui, Hsieh
Frank B, Hu
Katherine T, Mills
Bernadette T, Nguyen
Matthew J, O'Brien
Jonathan M, Samet
Gabriel I, Uwaifo
Jiang, He
Source :
JAMA Network Open. 5:e2238645
Publication Year :
2022
Publisher :
American Medical Association (AMA), 2022.

Abstract

ImportanceLow-carbohydrate diets decrease hemoglobin A1c (HbA1c) among patients with type 2 diabetes at least as much as low-fat diets. However, evidence on the effects of low-carbohydrate diets on HbA1c among individuals with HbA1c in the range of prediabetes to diabetes not treated by diabetes medications is limited.ObjectiveTo study the effect of a behavioral intervention promoting a low-carbohydrate diet compared with usual diet on 6-month changes in HbA1c among individuals with elevated untreated HbA1c.Design, Setting, and ParticipantsThis 6-month randomized clinical trial with 2 parallel groups was conducted from September 2018 to June 2021 at an academic medical center in New Orleans, Louisiana. Laboratory analysts were blinded to assignment. Participants were aged 40 to 70 years with untreated HbA1c of 6.0% to 6.9% (42-52 mmol/mol). Data analysis was performed from November 2021 to September 2022.InterventionsParticipants were randomized to a low-carbohydrate diet intervention (target Main Outcomes and MeasuresSix-month change in HbA1c was the primary outcome. Outcomes were measured at 0, 3, and 6 months.ResultsOf 2722 prescreened participants, 962 underwent screening, and 150 were enrolled (mean [SD] age, 58.9 [7.9] years; 108 women [72%]; 88 Black participants [59%]) and randomized to either the low-carbohydrate diet intervention (75 participants) or usual diet (75 participants) group. Six-month data were collected on 142 participants (95%). Mean (SD) HbA1c was 6.16% (0.30%) at baseline. Compared with the usual diet group, the low-carbohydrate diet intervention group had significantly greater 6-month reductions in HbA1c (net difference, –0.23%; 95% CI, –0.32% to –0.14%; P P P Conclusions and RelevanceIn this randomized clinical trial, a low-carbohydrate dietary intervention led to improvements in glycemia in individuals with elevated HbA1c not taking glucose-lowering medication, but the study was unable to evaluate its effects independently of weight loss. This diet, if sustained, might be a useful dietary approach for preventing and treating type 2 diabetes, but more research is needed.Trial RegistrationClinicalTrials.gov Identifier: NCT03675360

Details

ISSN :
25743805
Volume :
5
Database :
OpenAIRE
Journal :
JAMA Network Open
Accession number :
edsair.doi.dedup.....d13806e2bd1d86a35807d592c7fa29ae
Full Text :
https://doi.org/10.1001/jamanetworkopen.2022.38645