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PD-1 and PD-L1 are more highly expressed in high-grade bladder cancer than in low-grade cases: PD-L1 might function as a mediator of stage progression in bladder cancer
- Source :
- BMC Urology, BMC Urology, Vol 18, Iss 1, Pp 1-6 (2018)
- Publication Year :
- 2017
-
Abstract
- Background Bladder cancers have been characterized as a tumor group in which the immunological response is relatively well preserved. Programmed death ligand 1 (PD-L1, B7-H1, CD274) has been shown to be expressed in several malignancies, including bladder cancer. However, the clinicopathological impact of this biomarker has not yet been established. In the present study, a quantitative real-time polymerase chain reaction (qPCR) was performed using paired normal and cancerous bladder cancer tissue to investigate PD-1/PD-L1 gene expression. Methods We examined the mRNA expression of PD-1/PD-L1 by a qPCR using 58 pairs of normal and cancerous human bladder tissue specimens. We also examined the correlation with the expressions of the STAT1 and NFAT genes, which are thought to be upstream and downstream of the PD-L1 pathway, respectively. Results There were no significant differences between normal and cancerous tissue in the expression of the PD-1 and PD-L1 genes (p = 0.724 and p = 0.102, respectively). However, PD-1 and PD-L1 were both more highly expressed in high-grade bladder cancer than in low-grade bladder cancer (p
- Subjects :
- 0301 basic medicine
Male
Urology
Programmed Cell Death 1 Receptor
NFATc1
lcsh:RC870-923
B7-H1 Antigen
03 medical and health sciences
0302 clinical medicine
STAT1
PD-L1
Cell Line, Tumor
Gene expression
medicine
Biomarkers, Tumor
Humans
CD274
Stage (cooking)
Programmed death-ligand 1
Pathological
Aged
Retrospective Studies
Aged, 80 and over
Programmed cell death protein 1
Bladder cancer
biology
business.industry
NFAT
General Medicine
Middle Aged
medicine.disease
lcsh:Diseases of the genitourinary system. Urology
Gene Expression Regulation, Neoplastic
B7-H1
030104 developmental biology
Reproductive Medicine
Urinary Bladder Neoplasms
030220 oncology & carcinogenesis
Cancer research
biology.protein
Disease Progression
Biomarker (medicine)
Female
Neoplasm Grading
business
Research Article
Subjects
Details
- ISSN :
- 14712490
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC urology
- Accession number :
- edsair.doi.dedup.....d139e940296ba3996c515352410ebf24