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Direct Analysis of Biological Tissue by Paper Spray Mass Spectrometry
- Source :
- Analytical Chemistry. 83:1197-1201
- Publication Year :
- 2011
- Publisher :
- American Chemical Society (ACS), 2011.
-
Abstract
- Paper spray mass spectrometry (PS-MS) is explored as a fast and convenient way for direct analysis of molecules in tissues with minimum sample pretreatment. This technique allows direct detection of different types of molecules such as hormones, lipids and therapeutic drugs in short total analysis times (less than one minute) using a small volume of tissue sample (typically 1 mm3 or less). The tissue sample could be obtained by needle aspiration biopsy, by punch biopsy, or by rubbing a thin tissue section across the paper. There exists potential for the application of paper spray mass spectrometry together with tissue biopsy for clinical diagnostics.
- Subjects :
- Paper
Biopsy
Point-of-Care Systems
Sample (material)
Analytical chemistry
Mass spectrometry
Mass Spectrometry
Article
Specimen Handling
Analytical Chemistry
medicine
Animals
Humans
Sample preparation
Direct analysis
Chromatography
medicine.diagnostic_test
Small volume
Chemistry
Biological tissue
Lipids
Hormones
Needle aspiration biopsy
Rats
Biological Assay
Subjects
Details
- ISSN :
- 15206882 and 00032700
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Analytical Chemistry
- Accession number :
- edsair.doi.dedup.....d13d1424264fa79312b2f3052a66a705