Back to Search
Start Over
Stability of cognitive development during the first five years of life in relation to heavy metal concentrations in umbilical cord blood: Mothers' and Children's Environmental Health (MOCEH) birth cohort study
- Source :
- Science of The Total Environment. 609:153-159
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The objective of this study was to investigate stability of cognitive development during the first five years of life in relation to heavy metal concentrations in umbilical cord blood in Korean children. This research is part of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center prospective birth cohort study of pregnant women in Korea who were recruited from 2006 to 2010. We analyzed the complete follow-up data of children who were 5years-old in 2016. We measured lead, mercury, and cadmium levels in the umbilical cord blood of 251 children, and analyzed them, for whom neurodevelopmental data were available. We determined stability of cognitive development scores using three methods. First, we used partial correlation analyses to examine the stability of cognitive development at each measurement time. Second, we used Cramer's V to investigate the magnitude and direction of changes in cognitive development scores at each follow-up period among three groups (high, medium, and low scores). The results showed that cognitive development scores measured at the closest times had the strongest correlations, and the stability of cognitive development scores increased with age, from 6 to 60months. Groups at the extreme ends of cognitive development (high or low scores) had more stable scores, and this tendency was also stronger in infants >24months-old. The stability of cognitive development was unrelated to the umbilical cord level of heavy metals, based on analysis with Fisher's transformation. In conclusion, the present study showed that the cognitive development scores in a cohort of infants (6 to 60months-old) were stable.
- Subjects :
- Pediatrics
medicine.medical_specialty
Environmental Engineering
Umbilical cord
03 medical and health sciences
Child Development
Cognition
0302 clinical medicine
Pregnancy
Metals, Heavy
030225 pediatrics
Environmental health
Republic of Korea
Cognitive development
medicine
Humans
Environmental Chemistry
Prospective Studies
Prospective cohort study
Waste Management and Disposal
business.industry
Infant
Fetal Blood
medicine.disease
Pollution
Child development
medicine.anatomical_structure
Maternal Exposure
Child, Preschool
Cord blood
Cohort
Female
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00489697
- Volume :
- 609
- Database :
- OpenAIRE
- Journal :
- Science of The Total Environment
- Accession number :
- edsair.doi.dedup.....d13f258e07b3e4e5a92093a798e207cf