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Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts
- Source :
- Circulation, vol 126, iss 9, Circulation, Circulation, 126(9), 1040-U100, Circulation, vol. 126, no. 9, pp. 1040-1049
- Publication Year :
- 2012
- Publisher :
- eScholarship, University of California, 2012.
-
Abstract
- Background— American College of Cardiology/American Heart Association guidelines for the diagnosis and management of heart failure recommend investigating exacerbating conditions such as thyroid dysfunction, but without specifying the impact of different thyroid-stimulation hormone (TSH) levels. Limited prospective data exist on the association between subclinical thyroid dysfunction and heart failure events. Methods and Results— We performed a pooled analysis of individual participant data using all available prospective cohorts with thyroid function tests and subsequent follow-up of heart failure events. Individual data on 25 390 participants with 216 248 person-years of follow-up were supplied from 6 prospective cohorts in the United States and Europe. Euthyroidism was defined as TSH of 0.45 to 4.49 mIU/L, subclinical hypothyroidism as TSH of 4.5 to 19.9 mIU/L, and subclinical hyperthyroidism as TSH P for quadratic pattern P for trend P for trend=0.047). Risks remained similar after adjustment for cardiovascular risk factors. Conclusion— Risks of heart failure events were increased with both higher and lower TSH levels, particularly for TSH ≥10 and
- Subjects :
- Male
endocrine system diseases
Thyrotropin
heart failure
Comorbidity
030204 cardiovascular system & hematology
Cardiorespiratory Medicine and Haematology
Cardiovascular
thyroid
0302 clinical medicine
cohort studies
Risk Factors
80 and over
Prospective Studies
Prospective cohort study
Subclinical infection
Aged, 80 and over
medicine.diagnostic_test
Thyroid
Middle Aged
medicine.anatomical_structure
Heart Disease
Public Health and Health Services
Female
epidemiology
Cardiology and Cardiovascular Medicine
hormones, hormone substitutes, and hormone antagonists
Cohort study
Risk
Adult
endocrine system
medicine.medical_specialty
Management of heart failure
Clinical Sciences
030209 endocrinology & metabolism
Aged
Follow-Up Studies
Heart Failure/epidemiology
Humans
Hypothyroidism/blood
Hypothyroidism/epidemiology
Sensitivity and Specificity
Thyrotropin/blood
Thyroxine/blood
Thyroid function tests
Article
03 medical and health sciences
Hypothyroidism
Clinical Research
Physiology (medical)
Internal medicine
medicine
Metabolic and endocrine
business.industry
Thyroid Studies Collaboration
medicine.disease
meta-analysis
Thyroxine
Endocrinology
Cardiovascular System & Hematology
Heart failure
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Circulation, vol 126, iss 9, Circulation, Circulation, 126(9), 1040-U100, Circulation, vol. 126, no. 9, pp. 1040-1049
- Accession number :
- edsair.doi.dedup.....d145854a507eacb21a3bafbbabd28350