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Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts

Authors :
Gencer, B.
Collet, T.H.
Virgini, V.
Bauer, D.C.
Gussekloo, J.
Cappola, A.R.
Nanchen, D.
Elzen, W.P.J. den
Balmer, P.
Luben, R.N.
Iacoviello, M.
Triggiani, V.
Cornuz, J.
Newman, A.B.
Khaw, K.T.
Jukema, J.W.
Westendorp, R.G.J.
Vittinghoff, E.
Aujesky, D.
Rodondi, N.
Thyroid Studies Collaboration
Thyroid Studies Collaboration
Source :
Circulation, vol 126, iss 9, Circulation, Circulation, 126(9), 1040-U100, Circulation, vol. 126, no. 9, pp. 1040-1049
Publication Year :
2012
Publisher :
eScholarship, University of California, 2012.

Abstract

Background— American College of Cardiology/American Heart Association guidelines for the diagnosis and management of heart failure recommend investigating exacerbating conditions such as thyroid dysfunction, but without specifying the impact of different thyroid-stimulation hormone (TSH) levels. Limited prospective data exist on the association between subclinical thyroid dysfunction and heart failure events. Methods and Results— We performed a pooled analysis of individual participant data using all available prospective cohorts with thyroid function tests and subsequent follow-up of heart failure events. Individual data on 25 390 participants with 216 248 person-years of follow-up were supplied from 6 prospective cohorts in the United States and Europe. Euthyroidism was defined as TSH of 0.45 to 4.49 mIU/L, subclinical hypothyroidism as TSH of 4.5 to 19.9 mIU/L, and subclinical hyperthyroidism as TSH P for quadratic pattern P for trend P for trend=0.047). Risks remained similar after adjustment for cardiovascular risk factors. Conclusion— Risks of heart failure events were increased with both higher and lower TSH levels, particularly for TSH ≥10 and

Details

Database :
OpenAIRE
Journal :
Circulation, vol 126, iss 9, Circulation, Circulation, 126(9), 1040-U100, Circulation, vol. 126, no. 9, pp. 1040-1049
Accession number :
edsair.doi.dedup.....d145854a507eacb21a3bafbbabd28350