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Highlighted Prospects of an IgM/IgG Antibodies Test in Identifying Individuals With Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
- Source :
- Archives of Pathology & Laboratory Medicine. 145:39-45
- Publication Year :
- 2020
- Publisher :
- Archives of Pathology and Laboratory Medicine, 2020.
-
Abstract
- Context.— Covert severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections could be seeding new outbreaks. How to identify asymptomatic SARS-CoV-2 infections early has become a global focus. Objective.— To explore the roles of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies detection, nucleic acid tests, and computed tomography (CT) scanning to identify asymptomatic SARS-CoV-2 infection. Design.— The clinical data of 389 individuals with close contacts, including in general characteristics, SARS-CoV-2 etiology, serum-specific IgM and IgG antibody detection and CT imaging results, were systematically analyzed. Results.— The present study showed that only 89 of 389 individuals with close contacts were positive after the first nucleic acid test, while 300 individuals were still negative after 2 nucleic acid tests. Among the 300 individuals, 75 did not have pneumonia, and the other 225 individuals had pulmonary imaging changes. A total of 143 individuals were eventually diagnosed as having asymptomatic infection through IgM antibody and IgG antibody detection. The sensitivity, specificity, and false-negative rate of IgM and IgG antibody detection were approximately 97.1% (347 of 357), 95.3% (204 of 214), and 4.67% (10 of 214), respectively. It also indicated that during approximately 2 weeks, most individuals were both IgM positive and IgG positive, accounting for 68.57% (72 of 105). During approximately 3 weeks, the proportion of IgM-positive and IgG-positive individuals decreased to 8.57% (9 of 105), and the proportion of IgM-negative and IgG-positive individuals increased to 76.19% (80 of 105). Conclusions.— There are highlighted prospects of IgM/IgG antibody detection as a preferred method in identifying the individuals with asymptomatic SARS-CoV-2 infection, especially combined with nucleic acid tests and pulmonary CT scanning.
- Subjects :
- Adult
Male
China
Time Factors
Context (language use)
Antibodies, Viral
Asymptomatic
Immunoglobulin G
COVID-19 Serological Testing
030218 nuclear medicine & medical imaging
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
medicine
Humans
030212 general & internal medicine
Asymptomatic Infections
Lung
Pandemics
Retrospective Studies
biology
medicine.diagnostic_test
SARS-CoV-2
business.industry
COVID-19
Nucleic acid test
General Medicine
Middle Aged
medicine.disease
Medical Laboratory Technology
Pneumonia
Immunoglobulin M
COVID-19 Nucleic Acid Testing
Predictive value of tests
Immunology
biology.protein
Female
Antibody
medicine.symptom
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 15432165 and 00039985
- Volume :
- 145
- Database :
- OpenAIRE
- Journal :
- Archives of Pathology & Laboratory Medicine
- Accession number :
- edsair.doi.dedup.....d14e9d3d676eeace003e3ef83adafbf0