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Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study

Authors :
Rachel Nadif
Nicole Le Moual
Orianne Dumas
Hélène Huyvaert
Farid Zerimech
Miora Andrianjafimasy
Zeina Akiki
Régis Matran
Valérie Siroux
Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
Laboratoire de Biochimie et Biologie Moléculaire [CHRU Lille] (Pôle de Biologie Pathologie Génétique)
Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS)
Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB)
Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])
Université Lille Nord de France (COMUE)
Research was funded in part by the National Hospital program of clinical research (PHRCnational 2012, EvAdA), ANR-CES-2009, Region Nord Pas-de-Calais, Merck Sharp & Dohme (MSD), the GA2LEN project, Global Allergy and Asthma European Network, the Fonds AGIR pour les maladies chroniques, the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement n. PCOFUND-GA-2013-609102 through the PRESTIGE programme coordinated by Campus France, and by University of Versailles Saint-Quentin-en-Yvelines EDSP doctoral grant.
European Project: 609102,EC:FP7:PEOPLE,FP7-PEOPLE-2013-COFUND,PRESTIGE(2014)
Faraldo, Beatrice
PRES Towards International Gain of Excellence - PRESTIGE - - EC:FP7:PEOPLE2014-09-01 - 2019-08-31 - 609102 - VALID
Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])
Source :
European Respiratory Journal, European Respiratory Journal, European Respiratory Society, 2017, 50 (6), pp.1701193. ⟨10.1183/13993003.01193-2017⟩, European Respiratory Journal, 2017, 50 (6), pp.1701193. ⟨10.1183/13993003.01193-2017⟩
Publication Year :
2017
Publisher :
HAL CCSD, 2017.

Abstract

Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes.Cross-sectional analyses were conducted in 1388 adults (mean age 43 years, 44% with asthma) from the Epidemiological Study of the Genetics and Environment of Asthma (EGEA2). Three blood antioxidant enzyme activities (biomarkers of response to oxidative stress) and exhaled breath condensate 8-isoprostanes and plasma fluorescent oxidation products (FlOPs) levels (two biomarkers of damage) were measured. Associations between biomarkers and 1) ever asthma and 2) asthma attacks, asthma control and lung function in participants with asthma were evaluated using regression models adjusted for age, sex and smoking.Biomarkers of response were unrelated to asthma outcomes. Higher 8-isoprostane levels were significantly associated with ever asthma (odds ratio for one interquartile range increase 1.28 (95% CI 1.06–1.67). Among participants with asthma, 8-isoprostane levels were negatively associated with adult-onset asthma (0.63, 0.41–0.97) and FlOPs levels were positively associated with asthma attacks (1.33, 1.07–1.65), poor asthma control (1.30, 1.02–1.66) and poor lung function (1.34, 1.04–1.74).Our results suggest that 8-isoprostanes are involved in childhood-onset asthma and FlOPs are linked to asthma expression.

Details

Language :
English
ISSN :
09031936 and 13993003
Database :
OpenAIRE
Journal :
European Respiratory Journal, European Respiratory Journal, European Respiratory Society, 2017, 50 (6), pp.1701193. ⟨10.1183/13993003.01193-2017⟩, European Respiratory Journal, 2017, 50 (6), pp.1701193. ⟨10.1183/13993003.01193-2017⟩
Accession number :
edsair.doi.dedup.....d158f070617a933b0e8cf0e0d06048db