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Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study
- Source :
- European Respiratory Journal, European Respiratory Journal, European Respiratory Society, 2017, 50 (6), pp.1701193. ⟨10.1183/13993003.01193-2017⟩, European Respiratory Journal, 2017, 50 (6), pp.1701193. ⟨10.1183/13993003.01193-2017⟩
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes.Cross-sectional analyses were conducted in 1388 adults (mean age 43 years, 44% with asthma) from the Epidemiological Study of the Genetics and Environment of Asthma (EGEA2). Three blood antioxidant enzyme activities (biomarkers of response to oxidative stress) and exhaled breath condensate 8-isoprostanes and plasma fluorescent oxidation products (FlOPs) levels (two biomarkers of damage) were measured. Associations between biomarkers and 1) ever asthma and 2) asthma attacks, asthma control and lung function in participants with asthma were evaluated using regression models adjusted for age, sex and smoking.Biomarkers of response were unrelated to asthma outcomes. Higher 8-isoprostane levels were significantly associated with ever asthma (odds ratio for one interquartile range increase 1.28 (95% CI 1.06–1.67). Among participants with asthma, 8-isoprostane levels were negatively associated with adult-onset asthma (0.63, 0.41–0.97) and FlOPs levels were positively associated with asthma attacks (1.33, 1.07–1.65), poor asthma control (1.30, 1.02–1.66) and poor lung function (1.34, 1.04–1.74).Our results suggest that 8-isoprostanes are involved in childhood-onset asthma and FlOPs are linked to asthma expression.
- Subjects :
- Adult
Male
0301 basic medicine
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Cross-sectional study
Dinoprost
Nitric Oxide
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Interquartile range
immune system diseases
Forced Expiratory Volume
Internal medicine
Epidemiology
medicine
Humans
Exhaled breath condensate
Age of Onset
Asthma
business.industry
Odds ratio
Middle Aged
medicine.disease
3. Good health
respiratory tract diseases
Oxygen
Oxidative Stress
Cross-Sectional Studies
030104 developmental biology
Breath Tests
030228 respiratory system
Exhalation
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Regression Analysis
Female
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Age of onset
business
Biomarkers
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 09031936 and 13993003
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal, European Respiratory Journal, European Respiratory Society, 2017, 50 (6), pp.1701193. ⟨10.1183/13993003.01193-2017⟩, European Respiratory Journal, 2017, 50 (6), pp.1701193. ⟨10.1183/13993003.01193-2017⟩
- Accession number :
- edsair.doi.dedup.....d158f070617a933b0e8cf0e0d06048db