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More to come: Humoral immune responses in MS
- Source :
- Journal of Neuroimmunology. :13-21
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Interest in the role of B-cells in multiple sclerosis (MS) pathogenesis has increased, and a number of B-cell targeted therapies are currently in clinical trials. B-cells are key mediators of the humoral immune response, with roles including antibody production and acting as antigen presenting cells. Whilst previously, the presence of B-cells within MS plaques has been thought to be secondary to T-cell dysregulation, it is now becoming clear that B-cells play an independent role in disease. In this review we will discuss the potential role of B-cells in MS, how this influences our understanding of the disease, and potential therapeutic implications.
- Subjects :
- Multiple Sclerosis
Immunology
Disease
Pathogenesis
Antibodies, Monoclonal, Murine-Derived
Clinical Trials, Phase II as Topic
Immune system
Immunity
medicine
Humans
Immunology and Allergy
Antigen-presenting cell
B cell
B-Lymphocytes
biology
business.industry
Multiple sclerosis
medicine.disease
Immunity, Humoral
medicine.anatomical_structure
Neurology
biology.protein
Neurology (clinical)
Antibody
Rituximab
business
Subjects
Details
- ISSN :
- 01655728
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology
- Accession number :
- edsair.doi.dedup.....d16a6c61f04e78633f52424f31e127fb