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Tetanus and tetanus neurotoxin: From peripheral uptake to central nervous tissue targets
- Source :
- Journal of Neurochemistry. 158:1244-1253
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Tetanus is a deadly but preventable disease caused by a protein neurotoxin produced by Clostridium tetani. Spores of C. tetani may contaminate a necrotic wound and germinate into a vegetative bacterium that releases a toxin, termed tetanus neurotoxin (TeNT). TeNT enters the general circulation, binds to peripheral motor neurons and sensory neurons, and is transported retroaxonally to the spinal cord. It then enters inhibitory interneurons and blocks the release of glycine or GABA causing a spastic paralysis. This review attempts to correlate the metalloprotease activity of TeNT and its trafficking and localization into the vertebrate body to the nature and sequence of appearance of the symptoms of tetanus.
- Subjects :
- 0301 basic medicine
metalloprotease
Clostridium tetani
Neurotoxins
inhibitory interneurons
retroaxonal transport
tetanus
tetanus neurotoxin
Biology
Inhibitory postsynaptic potential
medicine.disease_cause
Biochemistry
Microbiology
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Tetanus Toxin
Tetanus Toxoid
medicine
Animals
Humans
Neurotoxin
Peripheral Nerves
Metalloproteinase
Tetanus
Toxin
Brain
medicine.disease
Spinal cord
body regions
030104 developmental biology
medicine.anatomical_structure
Spinal Cord
nervous system
Glycine
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14714159 and 00223042
- Volume :
- 158
- Database :
- OpenAIRE
- Journal :
- Journal of Neurochemistry
- Accession number :
- edsair.doi.dedup.....d1761a739f3c8d3a301b631841e1e8f3