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Antiinflammatory and antiācancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies
- Source :
- Phytotherapy Research. 34:685-720
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Inflammation is commonly characterized as a defensive and protective reaction of the body to various exogenous or endogenous stimuli, which aims to maintain the body health. Punica granatum (pomegranate) and its constituent ellagic acid (EA) are recently more taken into accounts since their promising pharmacological effects. Therefore, we aimed to obtain a comprehensive review regarding antiinflammatory, anticancer, and antioxidant activities of both pomegranate and EA and their possible involved mechanisms. In the procedure, scientific databases, including Web of Science, PubMed, Scopus, and Google Scholar, were searched in the English language, until the end of January 2019. Pomegranate belonging to the Punicaceae has been used for medical purposes from ancient and in different cultures. Several studies have also supported that EA is the major active compound of pomegranate and possesses antimutagenic, antiinflammatory, antifibrosis, anticancer, and antiaging properties. It has been suggested that pomegranate and EA possess promising immunomodulatory effects in preclinical models as well as human studies through regulation of the T-cell function and suppressing humoral immunity. Hopefully, we wish that this review and information could be helpful for designing further experiments to investigate the potential protective effects of pomegranate and EA.
- Subjects :
- Web of science
Anti-Inflammatory Agents
Drug Evaluation, Preclinical
Antineoplastic Agents
English language
Antioxidants
Pomegranate
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Ellagic Acid
medicine
Animals
Humans
Cells, Cultured
Pharmacology
0303 health sciences
Human studies
biology
Traditional medicine
Plant Extracts
business.industry
Clinical Studies as Topic
030302 biochemistry & molecular biology
Cancer
medicine.disease
biology.organism_classification
Disease Models, Animal
chemistry
Active compound
Fruit
030220 oncology & carcinogenesis
Punica
business
Ellagic acid
Subjects
Details
- ISSN :
- 10991573 and 0951418X
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Phytotherapy Research
- Accession number :
- edsair.doi.dedup.....d1793e32fde0dac3ff137144942ff9a8