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Genotoxicity Evaluation of the Soybean Isoflavone Genistein in Human Papillary Thyroid Cancer Cells. Study of Its Potential Use in Thyroid Cancer Therapy
Genotoxicity Evaluation of the Soybean Isoflavone Genistein in Human Papillary Thyroid Cancer Cells. Study of Its Potential Use in Thyroid Cancer Therapy
- Source :
- Nutrition and Cancer. 71:1335-1344
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Genistein is one of the several known isoflavonic phytoestrogens found in a number of plants, with soybeans and soy products being the primary food source. The aim of the study is to evaluate if genistein is able to exert antineoplastic action in primary human papillary thyroid cancer (PTC) cells. Thyroid tissues were treated with genistein (1-10-50-100 µM). Cell viability, proliferation, DNA primary damage and chromosomal damage were evaluated. An antiproliferative effect was induced by the highest doses of genistein, and such an effect was synergistically enhanced by the cotreatment with the antineoplastic drug sorafenib. Comet assay did not show any genotoxic effect in terms of primary DNA damage at all the times (4 and 24 h) and tested doses. A reduction of hydrogen peroxide-induced DNA primary damage in primary thyrocytes from PTC cells pretreated with genistein was observed. Data suggest that genistein exerts antineoplastic action, does not induce genotoxic effects while reduces oxidative-induced DNA damage in primary thyrocytes from PTC cells, supporting its possible use in therapeutic intervention.
- Subjects :
- 0301 basic medicine
endocrine system
Cancer Research
Medicine (miscellaneous)
Genistein
Phytoestrogens
macromolecular substances
medicine.disease_cause
Papillary thyroid cancer
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Tumor Cells, Cultured
medicine
Humans
Thyroid Neoplasms
Thyroid cancer
Cell Proliferation
030109 nutrition & dietetics
Nutrition and Dietetics
Mutagenicity Tests
business.industry
fungi
Thyroid
food and beverages
Isoflavones
medicine.disease
medicine.anatomical_structure
Oncology
chemistry
Thyroid Cancer, Papillary
030220 oncology & carcinogenesis
Cancer research
Soybeans
Mutagenicity Test
business
Genotoxicity
DNA Damage
Subjects
Details
- ISSN :
- 15327914 and 01635581
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Nutrition and Cancer
- Accession number :
- edsair.doi.dedup.....d18b9a4517690a5393eccb3e59c9770b
- Full Text :
- https://doi.org/10.1080/01635581.2019.1604004