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In Vivo Measurement of Cervical Spinal Cord Deformation During Traumatic Spinal Cord Injury in a Rodent Model
- Source :
- Annals of Biomedical Engineering. 44:1285-1298
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- The spinal cord undergoes physical deformation during traumatic spinal cord injury (TSCI), which results in biological damage. This study demonstrates a novel approach, using magnetic resonance imaging and image registration techniques, to quantify the three-dimensional deformation of the cervical spinal cord in an in vivo rat model. Twenty-four male rats were subjected to one of two clinically relevant mechanisms of TSCI (i.e. contusion and dislocation) inside of a MR scanner using a novel apparatus, enabling imaging of the deformed spinal cords. The displacement fields demonstrated qualitative differences between injury mechanisms. Three-dimensional Lagrangian strain fields were calculated, and the results from the contusion injury mechanism were deemed most reliable. Strain field error was assessed using a Monte Carlo approach, which showed that simulated normal strain error experienced a bias, whereas shear strain error did not. In contusion injury, a large region of dorso-ventral compressive strain was observed under the impactor which extended into the ventral region of the spinal cord. High tensile lateral strains under the impactor and compressive lateral strains in the lateral white matter were also observed in contusion. The ability to directly observe and quantify in vivo spinal cord deformation informs our knowledge of the mechanics of TSCI.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Contusions
0206 medical engineering
Biomedical Engineering
Strain (injury)
02 engineering and technology
Rats, Sprague-Dawley
White matter
03 medical and health sciences
0302 clinical medicine
In vivo
medicine
Animals
Displacement (orthopedic surgery)
Spinal Cord Injuries
medicine.diagnostic_test
business.industry
Biomechanics
Cervical Cord
Magnetic resonance imaging
Anatomy
medicine.disease
Spinal cord
Magnetic Resonance Imaging
020601 biomedical engineering
Disease Models, Animal
medicine.anatomical_structure
Stress, Mechanical
Deformation (engineering)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15739686 and 00906964
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Annals of Biomedical Engineering
- Accession number :
- edsair.doi.dedup.....d1acd03cb7ec4ce712aefa71bb8b4366