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Anti-bacterial activity of chitosan loaded plant essential oil against multi drug resistant K. pneumoniae
- Source :
- Saudi Journal of Biological Sciences, Vol 27, Iss 12, Pp 3449-3455 (2020), Saudi Journal of Biological Sciences
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- The development of antibiotic resistant in K. pneumoniae is an emerging thread worldwide due to the poor antimicrobial drugs. To overcome this issue, researchers are focused on plant material and their essential oils to fight against multi drug resistant bacteria. In this context, the current study was concentrated in medicinal plant of guva leaves and their essential oils to combat multi drug resistant bacterial infections. The essential oils were successfully screened and confirmed by HRLC-MS analysis. The anti-bacterial ability of the compounds were loaded into the chitosan nanoparticles and proved by FT-IR analysis. In addition, the chitosan loaded essential oils morphology was compared with chitosan alone in SEM analysis and suggested that the material was loaded successfully. Further, the anti-bacterial ability of the chitosan loaded essential oils were primarily confirmed by agar well diffusion method. At the 100 µg/mL of lowest concentration of chitosan loaded essential oils, the multi-drug resistant K. pneumoniae was inhibited with 96% and confirmed by minimum inhibition concentration experiment. Hence, all the experiments were proved that the essential oils were successfully loaded into the chitosan nanoparticles, and it has more anti-bacterial activity against multi-drug resistant K. pneumoniae.
- Subjects :
- 0106 biological sciences
0301 basic medicine
Multi drug resistant bacteria
Multi-drug resistant bacteria
01 natural sciences
law.invention
Chitosan
03 medical and health sciences
chemistry.chemical_compound
Antibiotic resistance
law
Food science
lcsh:QH301-705.5
Essential oil
Nanomaterials
Chemistry
Medicinal plant
K pneumoniae
Antimicrobial
Anti-bacterial activity
030104 developmental biology
lcsh:Biology (General)
Essential oils
Multi drug resistant
Original Article
Anti bacterial
General Agricultural and Biological Sciences
Minimum inhibition concentration
010606 plant biology & botany
Subjects
Details
- Language :
- English
- Volume :
- 27
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Saudi Journal of Biological Sciences
- Accession number :
- edsair.doi.dedup.....d1c4638ab7fc0d7af2792a1ed0b02317