Back to Search
Start Over
Antimalaria activity of ethanolic extract of Tetrapleura tetraptera fruit
- Source :
- Journal of ethnopharmacology. 111(3)
- Publication Year :
- 2006
-
Abstract
- The in vivo antiplasmodial activity of the ethanol fruit extract of Tetrapleura tetraptera used as spice and in the treatment of various ailment in Niger Delta region of Nigeria was evaluated in Plasmodium berghei infected mice. Tetrapleura tetraptera (300-900 mg/kg day) exhibited significant (P < 0.05) blood schizonticidal activity both in 4-day early infection test and in established infection with a considerable mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg day. The fruit extract possesses significant (P < 0.05) antiplasmodial activity with may have contributed to the immune status of the Nigerians against malaria in addition to its nutritive value.
- Subjects :
- Male
Tetrapleura tetraptera
Plasmodium berghei
Pharmacognosy
Median lethal dose
law.invention
Lethal Dose 50
Antimalarials
Mice
In vivo
law
Chloroquine
parasitic diseases
Drug Discovery
medicine
Toxicity Tests, Acute
Animals
Tetrapleura
Medicine, African Traditional
Pharmacology
biology
Traditional medicine
Dose-Response Relationship, Drug
Plant Extracts
biology.organism_classification
Malaria
Survival Rate
Disease Models, Animal
Fruit
Female
Phytotherapy
medicine.drug
Subjects
Details
- ISSN :
- 03788741
- Volume :
- 111
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of ethnopharmacology
- Accession number :
- edsair.doi.dedup.....d1d2b33f86ee22bd540bcaaaebb7cf96