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ETAReceptor Blockade Potentiates the Bronchoconstrictor Response to ET-1 in the Guinea Pig Airway
- Source :
- Biochemical and Biophysical Research Communications. 225:225-231
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- The effect of ETA receptor blockade on the bronchopulmonary response to endothelin-1 was determined in the airway of the anesthetized, spontaneously breathing guinea pig. Endothelin-1 administered as an aerosol increased lung resistance and decreased dynamic lung compliance. Delivery of the ETA receptor antagonist, FR139317, 5 min prior to giving endothelin-1 greatly potentiated these changes. A lower dose of endothelin-1 that had no effect on resistance or compliance produced large and significant changes when pretreated with FR139317. In contrast, aerosolized FR139317 had no effect on the bronchopulmonary response to intravenously administered endothelin-1. These data suggest a non-contractile function of ETA receptors accessible from the airways that serve to buffer the constrictor effects of non-ETA receptors.
- Subjects :
- Endothelin Receptor Antagonists
Male
medicine.hormone
Indoles
Time Factors
Guinea Pigs
Biophysics
Bronchi
Pulmonary compliance
Pharmacology
Biochemistry
Drug Administration Schedule
Bronchoconstrictor Agents
Endothelins
Guinea pig
Airway resistance
medicine
Animals
Receptor
Lung
Lung Compliance
Molecular Biology
Aerosols
Analysis of Variance
Receptors, Endothelin
Chemistry
Azepines
Cell Biology
Anatomy
respiratory system
Receptor, Endothelin A
Blockade
medicine.anatomical_structure
cardiovascular system
Airway
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 225
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....d1eb358c5f4039c8987a80280e4ef566