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Effects of Adiponectin on Diastolic Function in Mice Underwent Transverse Aorta Constriction
- Source :
- Journal of Cardiovascular Translational Research
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Diastolic dysfunction is common in various cardiovascular diseases, which could be affected by adiponectin (APN). Nevertheless, the effects of APN on diastolic dysfunction in pressure overload model induced by transverse aorta constriction (TAC) remain to be further elucidated. Here, we demonstrated that treatment of APN attenuated diastolic dysfunction and cardiac hypertrophy in TAC mice. Notably, APN also improved active relaxation of adult cardiomyocytes, increased N2BA/N2B ratios of titin isoform, and reduced collagen type I to type III ratio and lysyl oxidase (Lox) expressions in the myocardial tissue. Moreover, APN supplementation suppressed TAC-induced oxidative stress. In vitro, inhibition of AMPK by compound C (Cpc) abrogated the effect of APN on modulation of titin isoform shift and the anti-hypertrophic effect of APN on cardiomyocytes induced by AngII. In summary, our findings indicate that APN could attenuate diastolic dysfunction in TAC mice, which are at least partially mediated by AMPK pathway. Electronic supplementary material The online version of this article (10.1007/s12265-019-09913-1) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
AMPK
0301 basic medicine
Titin
Pharmaceutical Science
AMP-Activated Protein Kinases
030204 cardiovascular system & hematology
medicine.disease_cause
Ventricular Function, Left
Ventricular Dysfunction, Left
0302 clinical medicine
Diastole
Myocytes, Cardiac
Cells, Cultured
Genetics (clinical)
Ventricular Remodeling
biology
Extracellular Matrix
Diastolic dysfunction
Molecular Medicine
Hypertrophy, Left Ventricular
Original Article
Adiponectin
Cardiology and Cardiovascular Medicine
hormones, hormone substitutes, and hormone antagonists
medicine.medical_specialty
animal structures
Lysyl oxidase
Constriction
03 medical and health sciences
Internal medicine
Genetics
medicine
Animals
Pressure overload
Transverse aorta constriction
business.industry
Fibrosis
Mice, Inbred C57BL
Disease Models, Animal
Oxidative Stress
030104 developmental biology
Endocrinology
biology.protein
business
Protein Kinases
Oxidative stress
Subjects
Details
- ISSN :
- 19375395 and 19375387
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Translational Research
- Accession number :
- edsair.doi.dedup.....d1ed591f67ac417910b4e210ed66c43d