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Insulin dysregulation in horses with induced obesity
- Source :
- Pesquisa Veterinária Brasileira v.40 n.1 2020, Pesquisa Veterinária Brasileira, Colégio Brasileiro de Patologia Animal (CBPA), instacron:EMBRAPA, Pesquisa Veterinária Brasileira, Vol 40, Iss 1, Pp 39-45 (2020), Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2020
- Publisher :
- Colégio Brasileiro de Patologia Animal - CBPA, 2020.
-
Abstract
- Insulin deregulation (ID) is a central player in the pathophysiology of equine metabolic syndrome (EMS), which is associated with generalized and/or regional obesity. The objective of this experiment was to characterize the alterations in the hormonal profile in horses exposed to a hypercaloric diet. A total of nine Mangalarga Marchador adult horses with initial body condition score (BCS) of 2.9±1/9 (mean±SD) were submitted to a high calorie grain-rich diet for 5 months. The data was collected before the start of the experiment and every 15 days until the end of the experiment and glucose and insulin concentrations were measured in the plasma. Proxies G:I, RISQI, HOMA-IR and MIRG were calculated. The low-dose oral glucose tolerance test (OGTT) was performed and the total area under the glucose (GTA) and insulin (ITA) curves at three different timepoints (before inducing obesity, after 90 days and after 150 days) was used. Analysis of variance of the results was performed considering the time effects and the means were compared with repeated measures by the Tukey’s test (P≤0.05). The ID was observed during the first 90 days of the experiment and was characterized as a decompensated ID, showing an increase of basal glucose and insulin plasma levels, changes in all proxies and a significant increase in GTA (P
- Subjects :
- Mangalarga Marchador horses
medicine.medical_specialty
040301 veterinary sciences
medicine.medical_treatment
Veterinary medicine
obesity induction induced metabolic syndrome
0403 veterinary science
Insulin resistance
Internal medicine
insulin resistance
SF600-1100
Hyperinsulinemia
Medicine
overweight
horses
General Veterinary
biology
business.industry
Insulin
0402 animal and dairy science
Mangalarga
04 agricultural and veterinary sciences
Insulin dysregulation
biology.organism_classification
medicine.disease
040201 dairy & animal science
Obesity
Endocrinology
Basal (medicine)
Equine metabolic syndrome
Analysis of variance
business
DIETA ANIMAL
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Pesquisa Veterinária Brasileira v.40 n.1 2020, Pesquisa Veterinária Brasileira, Colégio Brasileiro de Patologia Animal (CBPA), instacron:EMBRAPA, Pesquisa Veterinária Brasileira, Vol 40, Iss 1, Pp 39-45 (2020), Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Accession number :
- edsair.doi.dedup.....d1f44b02ceb29195c438fc67778927bb