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Resectable extra-pleural and extra-meningeal solitary fibrous tumours: A multi-centre prognostic study
- Source :
- Europe PubMed Central
- Publication Year :
- 2015
-
Abstract
- Background Extra-pleural and extra-meningeal solitary fibrous tumour (SFT) is a rare sarcoma histotype curable with surgery in the majority of patients. The behaviour of these tumours ranges from indolent/very low grade to malignant/high grade but it is still not possible to accurately predict prognosis after surgery. We have investigated a multi-centre series to stratify the risk of recurrence to patients with SFTs. Methods We retrospectively analysed the data from 243 patients who underwent surgery (2002–2011) at four sarcoma referral centres. Results Upon univariate analysis, hypercellularity, atypia, necrosis, high mitotic rate (ie >4 mitoses/10 HPF) were associated with both disease-free and overall survival. Surgical margins were a significant prognostic factor for disease-free (P = 0.007) but not for overall survival. Unexpectedly, larger tumour size was associated with a better prognosis (P = 0.038) and fewer recurrences (P = 0.024). Upon multivariable analysis, high mitotic rate (hazard ratio, HR = 2.85, P = 0.002), cellular atypia (HR = 1.62, P = 0.015) and hypercellularity (HR = 1.82, P = 0.031) were significantly associated with recurrences. A SFT recurrence score has been provided to stratify risk of recurrence. Conclusion This study provides a prognostic model to stratify risk of recurrence in patients with resectable SFTs. This allows clinician to decide on an optimal follow-up strategy and to select patients that may benefit from adjuvant treatments.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Solitary fibrous tumor
Mitotic index
Solitary fibrous tumour
03 medical and health sciences
Necrosis
0302 clinical medicine
Predictive Value of Tests
medicine
Atypia
Mitotic Index
Humans
Aged
Retrospective Studies
Univariate analysis
Haemangiopericytoma
business.industry
Hazard ratio
Margins of Excision
Sarcoma
Retrospective cohort study
Prognosis
Female
Middle Aged
Neoplasm Recurrence, Local
Solitary Fibrous Tumors
Surgery
Oncology
General Medicine
medicine.disease
Neoplasm Recurrence
030104 developmental biology
Local
030220 oncology & carcinogenesis
Predictive value of tests
Radiology
business
Subjects
Details
- ISSN :
- 15322157
- Volume :
- 42
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....d211b622ef09fe207ba93f91d8095d95