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Imaging in endocrinology: 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in differentiated thyroid carcinoma: clinical indications and controversies in diagnosis and follow-up
- Publication Year :
- 2015
- Publisher :
- Bioscientifica Limited:22 Apex Court, Woodlands, Bradley, Bristol BS32 4JT United Kingdom:011 44 1454 619036, EMAIL: sales@endocrinology.org, INTERNET: http://www.endocrinology.org, Fax: 011 44 1454 616071, 2015.
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Abstract
- In recent years, 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT) has emerged as an important tool for the postoperative management of patients with differentiated thyroid cancer (DTC) and it is widely used in selected clinical situations. The most valuable role that FDG-PET/CT plays in clinical practice is that it can be used to obtain prognostic information in patients with increasing thyroglobulin (Tg) levels and negative 131I whole-body scan post-thyroidectomy and radioiodine (RAI) ablation. FDG-PET/CT may also have a potential role in the initial staging and follow-up of high-risk patients with aggressive histological subtypes, in the identification of patients who are at the highest risk of disease-specific mortality, in the management of patients with RAI-refractory disease, in clinical trials of novel targeted therapies in patients with advanced metastatic disease, and in the evaluation of thyroid nodules with indeterminate fine-needle aspiration for cytology. However, several controversies remain to be resolved, namely: the cutoff value of Tg in the selection of DTC patients for FDG-PET/CT, whether FDG-PET/CT scanning should be performed under thyrotropin stimulation or suppression, and the clinical significance of thyroid FDG-PET/CT incidentalomas. The aim of the present article is to provide an overview of the data about the molecular basis for, clinical indications of, and controversies related to the use of FDG-PET/CT in patients with DTC.
- Subjects :
- Thyroid nodules
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Multimodal Imaging
Iodine Radioisotope
Thyroid carcinoma
Iodine Radioisotopes
Endocrinology
Fluorodeoxyglucose F18
Internal medicine
medicine
Humans
Clinical significance
Whole Body Imaging
Thyroid Neoplasms
Thyroid cancer
Thyroid Neoplasm
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
medicine.diagnostic_test
business.industry
Medicine (all)
Thyroid
Carcinoma
Thyroidectomy
General Medicine
medicine.disease
medicine.anatomical_structure
Positron emission tomography
Positron-Emission Tomography
Radiopharmaceutical
Thyroglobulin
Radiopharmaceuticals
Nuclear medicine
business
Tomography, X-Ray Computed
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d21ad896d400723abd31003666d8ce5d