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Next-Generation Sequencing: An Emerging Tool for Drug Designing
- Source :
- Current pharmaceutical design. 25(31)
- Publication Year :
- 2019
-
Abstract
- Background: With the outbreak of high throughput next-generation sequencing (NGS), the biological research of drug discovery has been directed towards the oncology and infectious disease therapeutic areas, with extensive use in biopharmaceutical development and vaccine production. Method: In this review, an effort was made to address the basic background of NGS technologies, potential applications of NGS in drug designing. Our purpose is also to provide a brief introduction of various Nextgeneration sequencing techniques. Discussions: The high-throughput methods execute Large-scale Unbiased Sequencing (LUS) which comprises of Massively Parallel Sequencing (MPS) or NGS technologies. The Next geneinvolved necessarily executes Largescale Unbiased Sequencing (LUS) which comprises of MPS or NGS technologies. These are related terms that describe a DNA sequencing technology which has revolutionized genomic research. Using NGS, an entire human genome can be sequenced within a single day. Conclusion: Analysis of NGS data unravels important clues in the quest for the treatment of various lifethreatening diseases and other related scientific problems related to human welfare.
- Subjects :
- Human welfare
Computer science
infectious disease
Genomics
Computational biology
HIGH-THROUGHPUT
DNA sequencing
high throughput sequencing
03 medical and health sciences
0302 clinical medicine
Next generation sequencing
Drug Discovery
Humans
human welfare
030304 developmental biology
Pharmacology
0303 health sciences
Massive parallel sequencing
CHALLENGES
Drug discovery
Genome, Human
High-Throughput Nucleotide Sequencing
Large-scale Unbiased Sequencing (LUS)
DNA
Sequence Analysis, DNA
INSIGHTS
Biopharmaceutical
Infectious disease (medical specialty)
030220 oncology & carcinogenesis
Drug Design
TECHNOLOGIES
Human genome
Subjects
Details
- ISSN :
- 18734286
- Volume :
- 25
- Issue :
- 31
- Database :
- OpenAIRE
- Journal :
- Current pharmaceutical design
- Accession number :
- edsair.doi.dedup.....d2269a35dca8b31a0f4d50c087e22d7c