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Clinicopathological correlation of radiologic measurement of post-therapy tumor size and tumor volume for pancreatic ductal adenocarcinoma

Authors :
Anshuman Agrawal
Eugene J. Koay
Dongguang Wei
Ching Wei D. Tzeng
Anirban Maitra
Jeffrey E. Lee
Michael P. Kim
Matthew H.G. Katz
Laura R. Prakash
Priya Bhosale
Mohamed Zaid
Eric P. Tamm
Robert A. Wolff
Hua Wang
Huamin Wang
Asif Rashid
Gauri R. Varadhachary
Source :
Pancreatology, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], vol 21, iss 1
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

ObjectivesTumor size measurement is critical for accurate tumor staging in patients with pancreatic ductal adenocarcinoma (PDAC). However, accurate tumor size measurement is challenging in patients who received neoadjuvant therapy before resection, due to treatment-induced fibrosis and tumor invasion beyond the grossly identified tumor area. In this study, we evaluated the correlation between the tumor size and tumor volume measured on post-therapy computed tomography (CT) scans and the pathological measurement. Also, we investigated the correlation between these measurements and clinicopathological parameters and survival.Materials and methodsRetrospectively, we evaluated 343 patients with PDAC who received neoadjuvant therapy, followed by pancreaticoduodenectomy and had pre-operative pancreatic protocol CT imaging. We measured the longest tumor diameter (RadL) and the radiological tumor volume (RadV) on the post-therapy CT scan, then we categorized RadL into four radiologic tumor stages (RTS) based on the current AJCC staging (8th edition) protocol and RadV based on the median. Pearson correlation or Spearman's coefficient (δ), T-test and ANOVA was used to test the correlation between the radiological and pathological measurement. Chi-square analysis was used to test the correlation with the tumor pathological response, lymph-node metastasis and margin status and Kaplan-Meier and Cox-proportional hazard for survival analysis. P-value < 0.05 was considered significant.ResultsAs a continuous variable, RadL showed a positive linear correlation with the post-therapy pathologic tumor size in the overall patient population (Pearson correlation coefficient: 0.72, P&nbsp

Details

ISSN :
14243903
Volume :
21
Database :
OpenAIRE
Journal :
Pancreatology
Accession number :
edsair.doi.dedup.....d22ff545e88c48de92d8bcb50efbc745
Full Text :
https://doi.org/10.1016/j.pan.2020.11.003