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Body weight and risk of breast cancer in BRCA1/2 mutation carriers

Authors :
Manders, P.
Pijpe, A.
Hooning, M.J.
Kluijt, I.
Vasen, H.F.
Hoogerbrugge, N.
Asperen, C.J. van
Meijers-Heijboer, H.
Ausems, M.G.
Os, T.A. van
Gomez-Garcia, E.B.
Brohet, R.M.
Leeuwen, F.E. van
Rookus, M.A.
Ligtenberg, M.J.L.
Clinical Genetics
Medical Oncology
Internal Medicine
Human genetics
VU University medical center
EMGO - Quality of care
CCA - Innovative therapy
Klinische Genetica
RS: GROW - School for Oncology and Reproduction
Department of Epidemiology
Netherlands Cancer Institute
Department of Human Genetics
Radboud University Medical Center [Nijmegen]
Department of Medical Oncology
Erasmus University Medical Center [Rotterdam] (Erasmus MC)
Family Cancer Clinic
The Netherlands Foundation for the Detection of Hereditary Tumours
Poortgebouw Zuid
Department of Clinical Genetics
Leiden University Medical Center (LUMC)
Department of Clinical Genetics and Human Genetics
VU University Medical Center [Amsterdam]
Department of Medical Genetics
University Medical Center [Utrecht]
Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC)
University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA)
Maastricht University Medical Centre (MUMC)
Maastricht University [Maastricht]-Maastricht University [Maastricht]
Department of Research and Education
Spaarne hospital
University of Groningen
Human Genetics
Source :
Breast Cancer Research and Treatment, 126(1), 193-202, Breast Cancer Research and Treatment, 126, 1, pp. 193-202, Breast Cancer Research and Treatment, 126(1), 193-202. Springer New York, Breast Cancer Research and Treatment, 126(1), 193-202. Springer, Cham, Breast Cancer Research and Treatment, Breast Cancer Research and Treatment, Springer Verlag, 2010, 126 (1), pp.193-202. ⟨10.1007/s10549-010-1120-8⟩, Breast Cancer Research and Treatment, 126(1), 193-202. SPRINGER, Breast Cancer Research and Treatment, 126, 193-202, Breast cancer research and treatment, 126(1), 193-202. Springer New York, Manders, P, Pijpe, A, Hooning, M J, Kluijt, I, Vasen, H F A, Hoogerbrugge, N, van Asperen, C J, Meijers-Heijboer, E J, Ausems, M G E M, van Os, T A M, Gomez-Garcia, E B, Brohet, R M, van Leeuwen, F E & Rookus, M A 2011, ' Body weight and risk of breast cancer in BRCA1/2 mutation carriers ', Breast Cancer Research and Treatment, vol. 126, no. 1, pp. 193-202 . https://doi.org/10.1007/s10549-010-1120-8
Publication Year :
2011

Abstract

Contains fulltext : 95679.pdf (Publisher’s version ) (Closed access) Obesity is an established risk factor for postmenopausal breast cancer in the general population. However, it is still unclear whether this association also exists in BRCA1/2 mutation carriers. We investigated the association between self-reported anthropometric measures and breast cancer risk in a nationwide retrospective cohort study, including 719 BRCA1/2 carriers, of whom 218 had been diagnosed with breast cancer within 10 years prior to questionnaire completion. All time-varying Cox proportional hazards analyses were stratified by menopausal status. For premenopausal breast cancer, no statistically significant associations were observed for any of the anthropometric measures. The association between body mass index (BMI) at age 18 and premenopausal breast cancer risk suggested a trend of decreasing risk with increasing BMI (HR(22.50-24.99 vs. 18.50-22.49) = 0.83, 95% CI = 0.47-1.44 and HR(>/= 25.00 vs. 18.50-22.49) = 0.41, 95% CI = 0.13-1.27). For postmenopausal breast cancer, being 1.67 m and taller increased the risk 1.7-fold (HR = 1.67, 95% CI = 1.01-2.74) when compared to a height /= 72 kg increased the risk of postmenopausal breast cancer 2.1-fold (95% CI = 1.23-3.59). A current BMI of >/= 25.0 kg/m(2), an adult weight gain of 5 kg or more, and a relative adult weight gain of 20% or more were all non-significantly associated with a 50-60% increased risk of postmenopausal breast cancer [HR = 1.46 (0.86-2.51), HR = 1.56 (95% CI = 0.85-2.87), and HR = 1.60 (95% CI = 0.97-2.63), respectively], when compared with having a healthy or stable weight. No associations for body weight or BMI at age 18 were observed. In conclusion, menopausal status seemed to modify the association between body weight and breast cancer risk among BRCA1/2 carriers. We observed no clear association between body weight and premenopausal breast cancer, while overweight and weight gain increased postmenopausal breast cancer risk. Carriers may reduce their risk of postmenopausal breast cancer by maintaining a healthy body weight throughout life.

Details

Language :
English
ISSN :
01676806 and 15737217
Database :
OpenAIRE
Journal :
Breast Cancer Research and Treatment, 126(1), 193-202, Breast Cancer Research and Treatment, 126, 1, pp. 193-202, Breast Cancer Research and Treatment, 126(1), 193-202. Springer New York, Breast Cancer Research and Treatment, 126(1), 193-202. Springer, Cham, Breast Cancer Research and Treatment, Breast Cancer Research and Treatment, Springer Verlag, 2010, 126 (1), pp.193-202. ⟨10.1007/s10549-010-1120-8⟩, Breast Cancer Research and Treatment, 126(1), 193-202. SPRINGER, Breast Cancer Research and Treatment, 126, 193-202, Breast cancer research and treatment, 126(1), 193-202. Springer New York, Manders, P, Pijpe, A, Hooning, M J, Kluijt, I, Vasen, H F A, Hoogerbrugge, N, van Asperen, C J, Meijers-Heijboer, E J, Ausems, M G E M, van Os, T A M, Gomez-Garcia, E B, Brohet, R M, van Leeuwen, F E & Rookus, M A 2011, ' Body weight and risk of breast cancer in BRCA1/2 mutation carriers ', Breast Cancer Research and Treatment, vol. 126, no. 1, pp. 193-202 . https://doi.org/10.1007/s10549-010-1120-8
Accession number :
edsair.doi.dedup.....d246d8fd176a3775aaa19c174c615530
Full Text :
https://doi.org/10.1007/s10549-010-1120-8⟩