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Body weight and risk of breast cancer in BRCA1/2 mutation carriers
- Source :
- Breast Cancer Research and Treatment, 126(1), 193-202, Breast Cancer Research and Treatment, 126, 1, pp. 193-202, Breast Cancer Research and Treatment, 126(1), 193-202. Springer New York, Breast Cancer Research and Treatment, 126(1), 193-202. Springer, Cham, Breast Cancer Research and Treatment, Breast Cancer Research and Treatment, Springer Verlag, 2010, 126 (1), pp.193-202. ⟨10.1007/s10549-010-1120-8⟩, Breast Cancer Research and Treatment, 126(1), 193-202. SPRINGER, Breast Cancer Research and Treatment, 126, 193-202, Breast cancer research and treatment, 126(1), 193-202. Springer New York, Manders, P, Pijpe, A, Hooning, M J, Kluijt, I, Vasen, H F A, Hoogerbrugge, N, van Asperen, C J, Meijers-Heijboer, E J, Ausems, M G E M, van Os, T A M, Gomez-Garcia, E B, Brohet, R M, van Leeuwen, F E & Rookus, M A 2011, ' Body weight and risk of breast cancer in BRCA1/2 mutation carriers ', Breast Cancer Research and Treatment, vol. 126, no. 1, pp. 193-202 . https://doi.org/10.1007/s10549-010-1120-8
- Publication Year :
- 2011
-
Abstract
- Contains fulltext : 95679.pdf (Publisher’s version ) (Closed access) Obesity is an established risk factor for postmenopausal breast cancer in the general population. However, it is still unclear whether this association also exists in BRCA1/2 mutation carriers. We investigated the association between self-reported anthropometric measures and breast cancer risk in a nationwide retrospective cohort study, including 719 BRCA1/2 carriers, of whom 218 had been diagnosed with breast cancer within 10 years prior to questionnaire completion. All time-varying Cox proportional hazards analyses were stratified by menopausal status. For premenopausal breast cancer, no statistically significant associations were observed for any of the anthropometric measures. The association between body mass index (BMI) at age 18 and premenopausal breast cancer risk suggested a trend of decreasing risk with increasing BMI (HR(22.50-24.99 vs. 18.50-22.49) = 0.83, 95% CI = 0.47-1.44 and HR(>/= 25.00 vs. 18.50-22.49) = 0.41, 95% CI = 0.13-1.27). For postmenopausal breast cancer, being 1.67 m and taller increased the risk 1.7-fold (HR = 1.67, 95% CI = 1.01-2.74) when compared to a height /= 72 kg increased the risk of postmenopausal breast cancer 2.1-fold (95% CI = 1.23-3.59). A current BMI of >/= 25.0 kg/m(2), an adult weight gain of 5 kg or more, and a relative adult weight gain of 20% or more were all non-significantly associated with a 50-60% increased risk of postmenopausal breast cancer [HR = 1.46 (0.86-2.51), HR = 1.56 (95% CI = 0.85-2.87), and HR = 1.60 (95% CI = 0.97-2.63), respectively], when compared with having a healthy or stable weight. No associations for body weight or BMI at age 18 were observed. In conclusion, menopausal status seemed to modify the association between body weight and breast cancer risk among BRCA1/2 carriers. We observed no clear association between body weight and premenopausal breast cancer, while overweight and weight gain increased postmenopausal breast cancer risk. Carriers may reduce their risk of postmenopausal breast cancer by maintaining a healthy body weight throughout life.
- Subjects :
- Cancer Research
Epidemiology
Overweight
SUSCEPTIBILITY
Weight Gain
Polymerase Chain Reaction
Body Mass Index
Cohort Studies
0302 clinical medicine
Breast cancer
Risk Factors
Netherlands
2. Zero hunger
0303 health sciences
education.field_of_study
Obstetrics
BRCA1 Protein
Genetic Carrier Screening
WOMEN
DNA, Neoplasm
Middle Aged
Prognosis
3. Good health
Postmenopause
Survival Rate
Oncology
030220 oncology & carcinogenesis
OBESITY
Female
LIFE-STYLE
Breast disease
medicine.symptom
Adult
medicine.medical_specialty
Population
Hereditary cancer and cancer-related syndromes Genetics and epigenetic pathways of disease [ONCOL 1]
Breast Neoplasms
Body weight Breast cancer BRCA1/2 HEBON Epidemiology ovarian-cancer estrogen-receptor physical-activity life-style mass index geo-hebon obesity cohort women susceptibility
OVARIAN-CANCER
03 medical and health sciences
Young Adult
MASS INDEX
SDG 3 - Good Health and Well-being
BRCA1/2
medicine
Humans
COHORT
Risk factor
education
HEBON
030304 developmental biology
Retrospective Studies
Gynecology
BRCA2 Protein
Hereditary cancer and cancer-related syndromes [ONCOL 1]
business.industry
Cancer
Body weight
medicine.disease
ESTROGEN-RECEPTOR
PHYSICAL-ACTIVITY
Premenopause
GEO-HEBON
Case-Control Studies
Mutation
Hereditary cancer and cancer-related syndromes Genomic disorders and inherited multi-system disorders [ONCOL 1]
business
Weight gain
Body mass index
Subjects
Details
- Language :
- English
- ISSN :
- 01676806 and 15737217
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment, 126(1), 193-202, Breast Cancer Research and Treatment, 126, 1, pp. 193-202, Breast Cancer Research and Treatment, 126(1), 193-202. Springer New York, Breast Cancer Research and Treatment, 126(1), 193-202. Springer, Cham, Breast Cancer Research and Treatment, Breast Cancer Research and Treatment, Springer Verlag, 2010, 126 (1), pp.193-202. ⟨10.1007/s10549-010-1120-8⟩, Breast Cancer Research and Treatment, 126(1), 193-202. SPRINGER, Breast Cancer Research and Treatment, 126, 193-202, Breast cancer research and treatment, 126(1), 193-202. Springer New York, Manders, P, Pijpe, A, Hooning, M J, Kluijt, I, Vasen, H F A, Hoogerbrugge, N, van Asperen, C J, Meijers-Heijboer, E J, Ausems, M G E M, van Os, T A M, Gomez-Garcia, E B, Brohet, R M, van Leeuwen, F E & Rookus, M A 2011, ' Body weight and risk of breast cancer in BRCA1/2 mutation carriers ', Breast Cancer Research and Treatment, vol. 126, no. 1, pp. 193-202 . https://doi.org/10.1007/s10549-010-1120-8
- Accession number :
- edsair.doi.dedup.....d246d8fd176a3775aaa19c174c615530
- Full Text :
- https://doi.org/10.1007/s10549-010-1120-8⟩