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Increased B7-H4 expression during esophageal squamous cell carcinogenesis is associated with IL-6/STAT3 signaling pathway activation in mice
- Source :
- Oncology Letters
- Publication Year :
- 2017
- Publisher :
- Spandidos Publications, 2017.
-
Abstract
- B7-homolog 4 (B7-H4), one of the costimulatory molecules of the B7 family, has been reported to be widely expressed in multiple types of cancer tissues, and to be important in tumor progression and poor prognosis. However, the role of B7-H4 in esophageal precancerous lesions has not been elucidated yet. In the present study, a model of esophageal squamous cell carcinogenesis was established in 208 C57BL/6 mice by 4-nitroquinoline-1-oxide (4NQO) drinking water of mice, and the changes in the expression of B7-H4 during the whole pathological process were investigated. Hematoxylin and eosin staining results demonstrated that the pathological stage was exacerbated with the increase in time of 4NQO-mediated carcinogenesis induction, and the pathological features were similar to those observed in humans. Immunohistochemistry results revealed that B7-H4 expression was upregulated and positively correlated with pathological stage (P
- Subjects :
- 0301 basic medicine
Cancer Research
precancerous condition
interleukin-6/signal transducer and activator of transcription 3 signaling pathway
medicine.disease_cause
Stat3 Signaling Pathway
03 medical and health sciences
0302 clinical medicine
esophageal carcinogenesis
4-nitroquinoline-1-oxide
Gene expression
medicine
STAT3
Oncogene
biology
Cluster of differentiation
Articles
Cell cycle
B7-homolog 4
030104 developmental biology
Oncology
Tumor progression
030220 oncology & carcinogenesis
biology.protein
Cancer research
Carcinogenesis
Subjects
Details
- ISSN :
- 17921082 and 17921074
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Oncology Letters
- Accession number :
- edsair.doi.dedup.....d27291178f2c6275d4c3b0c9b3ab7ae0