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Long-term survival among patients with gastrointestinal stromal tumors diagnosed after another malignancy: a SEER population-based study
- Source :
- World Journal of Surgical Oncology, World Journal of Surgical Oncology, Vol 18, Iss 1, Pp 1-12 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background To explore overall survival (OS) and GISTs-specific survival (GSS) among cancer survivors developing a second primary gastrointestinal stromal tumors (GISTs). Methods We conducted a cohort study, where patients with GISTs after another malignancy (AM-GISTs, n = 851) and those with only GISTs (GISTs-1, n = 7660) were identified from the Surveillance, Epidemiology, and End Results registries (1988–2016). Clinicopathologic characteristics and survival were compared between the two groups. Results The most commonly diagnosed first primary malignancy was prostate cancer (27.7%), followed by breast cancer (16.2%). OS among AM-GISTs was significantly inferior to that of GISTs-1; 10-year OS was 40.3% vs. 50.0%, (p < 0.001). A contrary finding was observed for GSS (10-year GSS 68.9% vs. 61.8%, p = 0.002). In the AM-GISTs group, a total of 338 patients died, of which 26.0% died of their initial cancer and 40.8% died of GISTs. Independent of demographics and clinicopathological characteristics, mortality from GISTs among AM-GISTs patients was decreased compared with their GISTs-1 counterparts (HR, 0.71; 95% CI, 0.59–0.84; p < 0.001), whereas OS was inferior among AM-GISTs (HR, 1.11; 95% CI, 0.99–1.25; p = 0.085). Conclusions AM-GISTs patients have decreased risk of dying from GISTs compared with GIST-1. Although another malignancy history does not seemingly affect OS for GISTs patients, clinical treatment of such patients should be cautious.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Stromal cell
Adolescent
Gastrointestinal Stromal Tumors
lcsh:Surgery
Kaplan-Meier Estimate
Population-based
Malignancy
lcsh:RC254-282
Risk Assessment
Gastroenterology
Young Adult
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Breast cancer
Cancer Survivors
Surgical oncology
Internal medicine
Epidemiology
medicine
Humans
neoplasms
Aged
Aged, 80 and over
business.industry
Research
Cancer
Neoplasms, Second Primary
lcsh:RD1-811
Second malignant neoplasms
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
medicine.disease
digestive system diseases
SEER
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Female
Surgery
business
Follow-Up Studies
SEER Program
Cohort study
Subjects
Details
- ISSN :
- 14777819
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- World Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....d2b22c6049d0cbbb6de73d77e6de1bb4