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Pancreatic Exocrine Insufficiency in Pancreatic Cancer
- Source :
- Nutrients, Nutrients, Vol 9, Iss 3, p 183 (2017)
- Publication Year :
- 2017
- Publisher :
- MDPI, 2017.
-
Abstract
- Cancer patients experience weight loss for a variety of reasons, commencing with the tumor’s metabolism (Warburg effect) and proceeding via cachexia to loss of appetite. In pancreatic cancer, several other factors are involved, including a loss of appetite with a particular aversion to meat and the incapacity of the pancreatic gland to function normally when a tumor is present in the pancreatic head. Pancreatic exocrine insufficiency is characterized by a deficiency of the enzymes secreted from the pancreas due to the obstructive tumor, resulting in maldigestion. This, in turn, contributes to malnutrition, specifically a lack of fat-soluble vitamins, antioxidants, and other micronutrients. Patients with pancreatic cancer and pancreatic exocrine insufficiency have, overall, an extremely poor prognosis with regard to surgical outcome and overall survival. Therefore, it is crucial to be aware of the mechanisms involved in the disease, to be able to diagnose pancreatic exocrine insufficiency early on, and to treat malnutrition appropriately, for example, with pancreatic enzymes.
- Subjects :
- medicine.medical_specialty
exocrine insufficiency
media_common.quotation_subject
pancreatic cancer
lcsh:TX341-641
Review
malnutrition
Gastroenterology
Cachexia
03 medical and health sciences
0302 clinical medicine
pancreas cancer
Weight loss
Internal medicine
Pancreatic cancer
medicine
Humans
Enzyme Replacement Therapy
pancreas
pancreatic surgery
media_common
Randomized Controlled Trials as Topic
pancreatic exocrine insufficiency
Nutrition and Dietetics
business.industry
vitamin
Cancer
Appetite
Vitamins
medicine.disease
Warburg effect
Pancreatic Neoplasms
Malnutrition
Endocrinology
medicine.anatomical_structure
exocrine insufficiency, pancreas, pancreas cancer
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Exocrine Pancreatic Insufficiency
medicine.symptom
Pancreas
business
lcsh:Nutrition. Foods and food supply
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 9
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....d2c96bacfcbda704b3cf071f8b013fe5