Back to Search
Start Over
Bariatric surgery in morbidly obese patients improves the atherogenic qualitative properties of the plasma lipoproteins
- Source :
- ATHEROSCLEROSIS, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Objective: The purpose of this study was to evaluate the effect of weight loss induced in morbidly obese subjects by Roux-en-Y gastric bypass bariatric surgery on the atherogenic features of their plasma lipoproteins. Methods: Twenty-one morbidly obese subjects undergoing bariatric surgery were followed up for up to 1 year after surgery. Plasma and lipoproteins were assayed for chemical composition and lipoprotein-associated phospholipase A2 (Lp-PLA2) activity. Lipoprotein size was assessed by non-denaturing polyacrylamide gradient gel electrophoresis, and oxidised LDL by ELISA. Liver samples were assayed for mRNA abundance of oxidative markers. Results: Lipid profile analysis revealed a reduction in the plasma concentrations of cholesterol and tri-glycerides, which were mainly associated with a significant reduction in the plasma concentration of circulating apoB-containing lipoproteins rather than with changes in their relative chemical composition. All patients displayed a pattern A phenotype of LDL subfractions and a relative increase in the anti-atherogenic plasma HDL-2 subfraction (> 2-fold; P < 0.001). The switch towards predominantly larger HDL particles was due to an increase in their relative cholesteryl ester content. Excess weight loss also led to a significant decrease in the plasma concentration of oxidised LDL (similar to-25%; P < 0.01) and in the total Lp-PLA2 activity. Interestingly, the decrease in plasma Lp-PLA2 was mainly attributed to a decrease in the apoB-containing lipoprotein-bound Lp-PLA2. Conclusion: Our data indicate that the weight loss induced by bariatric surgery ameliorates the atherogenicity of plasma lipoproteins by reducing the apoB-containing Lp-PLA2 activity and oxidised LDL, as well as increasing the HDL-2 subfraction. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
- Subjects :
- Adult
Male
Plasma lipoprotein
Weight loss
Very low-density lipoprotein
medicine.medical_specialty
HDL
Apolipoprotein B
Lipoproteins
Lipoprotein-associated phospholipase
Gastric Bypass
Oxidised LDL
Young Adult
chemistry.chemical_compound
High-density lipoprotein
A2 (Lp-PLA2)
Weight Loss
Humans
Medicine
Obesity
Bariatric surgery
biology
business.industry
Lipoprotein-associated phospholipase A2
Middle Aged
Atherosclerosis
medicine.disease
SCARB1
Obesity, Morbid
Surgery
chemistry
biology.protein
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 00219150
- Volume :
- 234
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....d2dd9782d93bd3263c42d37b170b2add