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The importance of the margin of resection and external radiation in non-lipomatous retroperitoneal sarcoma
- Source :
- Am J Surg
- Publication Year :
- 2020
-
Abstract
- BACKGROUND: Prior studies evaluating the impact of adjuvant or neoadjuvant radiation on clinical outcomes of patients with non-lipomatous retroperitoneal sarcoma have been underpowered. METHODS: We queried the National Cancer Database to identify patients undergoing surgical resection of retroperitoneal sarcoma with non-lipomatous histology from 2004 to 2016. Multivariable logistic regression and Cox proportional hazards modelling with patients stratified by tumor size were used to identify factors associated with overall survival. RESULTS: 3,394 patients met inclusion criteria. 592 had small (10 cm) tumors. Use of either neoadjuvant or adjuvant radiotherapy was associated with improved survival for patients with intermediate (neoadjuvant HR 0.67, CI [0.46, 0.98]; adjuvant HR 0.61, CI [0.50, 0.76]) and large (neoadjuvant HR 0.50, CI [0.37, 0.68]; adjuvant HR 0.56, CI [0.47, 0.69]) tumors, while adjuvant radiation therapy was associated with a survival benefit for small-sized tumors (HR 0.67, CI [0.46, 0.99]). CONCLUSIONS: Radiation therapy is associated with an overall survival benefit in patients presenting undergoing resection of non-lipomatous retroperitoneal sarcoma.
- Subjects :
- Adult
Male
medicine.medical_specialty
Databases, Factual
medicine.medical_treatment
030230 surgery
Logistic regression
Article
Resection
03 medical and health sciences
0302 clinical medicine
medicine
Retroperitoneal sarcoma
Humans
Retroperitoneal Neoplasms
Aged
Retrospective Studies
Proportional hazards model
business.industry
Cancer
Margins of Excision
Histology
Sarcoma
General Medicine
Middle Aged
medicine.disease
Neoadjuvant Therapy
Radiation therapy
Treatment Outcome
030220 oncology & carcinogenesis
Surgery
Female
Radiotherapy, Adjuvant
Radiology
business
Adjuvant
Subjects
Details
- ISSN :
- 18791883
- Volume :
- 221
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- American journal of surgery
- Accession number :
- edsair.doi.dedup.....d2eed78584d630f20430c870243cc872