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Impact of the Uncoupling Protein 1 on Cardiovascular Risk in Patients with Rheumatoid Arthritis
- Source :
- Cells, Vol 10, Iss 1131, p 1131 (2021), Cells, Volume 10, Issue 5
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Adiposity is strongly associated with cardiovascular (CV) morbidity. Uncoupling protein 1 (UCP1) increases energy expenditure in adipocytes and may counteract adiposity. Our objective was to investigate a connection between UCP1 expression and cardiovascular health in patients with rheumatoid arthritis (RA) in a longitudinal observational study. Transcription of UCP1 was measured by qPCR in the subcutaneous adipose tissue of 125 female RA patients and analyzed with respect to clinical parameters and the estimated CV risk. Development of new CV events and diabetes mellitus was followed for five years. Transcription of UCP1 was identified in 89 (71%) patients. UCP1 positive patients had often active RA disease (p = 0.017), high serum levels of IL6 (p = 0.0025) and were frequently overweight (p = 0.015). IL-6hiBMIhi patients and patients treated with IL6 receptor inhibitor tocilizumab had significantly higher levels of UCP1 compared to other RA patients (p &lt<br />0.0001, p = 0.032, respectively). Both UCP1hi groups displayed unfavorable metabolic profiles with high plasma glucose levels and high triglyceride-to-HDL ratios, which indicated insulin resistance. Prospective follow-up revealed no significant difference in the incidence of new CV and metabolic events in the UCP1hi groups and remaining RA patients. The study shows that high transcription of UCP1 in adipose tissue is related to IL6-driven processes and reflects primarily metabolic CV risk in female RA patients.
- Subjects :
- 0301 basic medicine
cardiovascular risk
rheumatoid arthritis
medicine.medical_specialty
QH301-705.5
UCP-1
Adipose tissue
Overweight
Article
Arthritis, Rheumatoid
03 medical and health sciences
chemistry.chemical_compound
tocilizumab
0302 clinical medicine
Tocilizumab
Insulin resistance
Risk Factors
Diabetes mellitus
Internal medicine
medicine
Humans
Prospective Studies
Biology (General)
Interleukin 6
Uncoupling Protein 1
Aged
030203 arthritis & rheumatology
IL-6
biology
business.industry
Interleukin-6
General Medicine
Middle Aged
medicine.disease
Prognosis
Thermogenin
adipose tissue
030104 developmental biology
Endocrinology
chemistry
Gene Expression Regulation
Cardiovascular Diseases
Rheumatoid arthritis
biology.protein
Female
medicine.symptom
business
Biomarkers
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 10
- Issue :
- 1131
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....d2f2d03eb6fc233e52f0ca8b1e5a5e40