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Serum antibody profiles in individuals with latent Mycobacterium tuberculosis infection
- Source :
- Microbiology and Immunology
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- One‐third of the world's humans has latent tuberculosis infection (LTBI), representing a large pool of potentially active TB. Recent LTBI carries a higher risk of disease progression than remote LTBI. Recent studies suggest important roles of antibodies in TB pathology, prompting us to investigate serum antibody profiles in a cohort with LTBI. In this single‐center prospective observational study, we analyzed IgG‐antibody concentrations against five major Mycobacterium tuberculosis (Mtb) antigens (including 6 kDa early secretory antigenic target (ESAT6), CFP10, and antigen 85A, which are expressed mainly in the growth phase; and mycobacterial DNA‐binding protein 1 (MDP1) and alpha‐crystallin like protein (Acr), which are expressed in the dormant phases) in individuals with recent (n=13) or remote (n=12) LTBI, no Mtb infection (n=19), or active TB (n=15). Antibody titers against ESAT6 and MDP1 were significantly higher in individuals with recent LTBI than in those with no Mtb infection or remote LTBI. All pairwise antibody titers against these five major antigens were significantly correlated throughout the stages of Mtb infection. Five individuals with recent LTBI had significantly higher antibody titers against ESAT6 (P = 0.03), Ag85A (P = 0.048), Acr (P = 0.057), and MDP1 (P = 0.0001) than in individuals with remote LTBI; they were also outside the normal range (+2 SDs). One of these individuals was diagnosed with active pulmonary TB at 18‐month follow‐up examination. These findings indicated that concentrations of antibodies against both multiplying and dormant Mtb are higher in recent LTBI and that individuals with markedly higher antibody titers may be appropriate candidates for prophylactic therapy.
- Subjects :
- Adult
Male
latent tuberculosis infection
Immunology
Biology
Microbiology
Serum antibody
Mycobacterium tuberculosis
03 medical and health sciences
Bacterial Proteins
Antigen
Latent Tuberculosis
Virology
medicine
Humans
Prospective Studies
alpha-Crystallins
Tuberculosis, Pulmonary
030304 developmental biology
Antigens, Bacterial
0303 health sciences
Latent tuberculosis
030306 microbiology
Antibody titer
Original Articles
Biomarker
Middle Aged
bacterial infections and mycoses
medicine.disease
biology.organism_classification
Antibodies, Bacterial
DNA-Binding Proteins
serum antibody
Immunoglobulin G
Cohort
biology.protein
Biomarker (medicine)
Original Article
mycobacterial DNA‐binding protein 1
Female
Antibody
Acyltransferases
Subjects
Details
- ISSN :
- 13480421 and 03855600
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Microbiology and Immunology
- Accession number :
- edsair.doi.dedup.....d3145ad6acfdb2a1ce18a5017b1e3ddd
- Full Text :
- https://doi.org/10.1111/1348-0421.12674