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Antibacterial evaluation and mode of action study of BIMQ, a novel bacterial cell division inhibitor
- Source :
- Biochemical and biophysical research communications. 514(4)
- Publication Year :
- 2019
-
Abstract
- The worldwide spreading of antibiotic resistant bacteria is currently an extremely serious health risk and therefore to develop new antibiotics is an urgent need. In the present study, the antibacterial activity of a new indolyl quinolinium compound and its underline mechanism were investigated. The compound shows an outstanding antibacterial activity against the tested Gram-positive bacteria. The MIC values are in the range of 1–4 μg/mL. The elongation of B. subtilis cells indicates that the compound can inhibit cell division effectively. In addition, the biochemical studies prove that the compound is able to disrupt FtsZ polymerization effectively through a stimulatory mechanism. Furthermore, the compound can delay the development of drug resistance mutants.
- Subjects :
- 0301 basic medicine
Staphylococcus aureus
Cell division
medicine.drug_class
Antibiotics
Biophysics
Drug resistance
Microbial Sensitivity Tests
Biochemistry
Bacterial cell structure
03 medical and health sciences
Structure-Activity Relationship
0302 clinical medicine
Drug Resistance, Bacterial
medicine
Mode of action
FtsZ
Molecular Biology
biology
Dose-Response Relationship, Drug
Molecular Structure
Chemistry
Quinolinium Compounds
Cell Biology
biology.organism_classification
Anti-Bacterial Agents
030104 developmental biology
030220 oncology & carcinogenesis
biology.protein
Antibacterial activity
Bacteria
Cell Division
Bacillus subtilis
Subjects
Details
- ISSN :
- 10902104
- Volume :
- 514
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Biochemical and biophysical research communications
- Accession number :
- edsair.doi.dedup.....d31c4987f6be2933b6984491af045e7b