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The efficacy of interleukin‐1 antagonist drugs in combination with colchicine in patients with FMF‐AA with colchicine resistance after kidney transplantation: A study with histopathologic evidence
- Source :
- Clinical Transplantation. 35
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- The efficacy of anti-interleukin-1 (IL-1) drugs in kidney transplant patients with FMF-AA who developed colchicine resistance has not been clearly demonstrated.Thirty nine kidney transplant recipients with FMF-AA were evaluated. Group 1 consisted of patients who were in remission after transplantation with colchine and Group 2 included those who developed colchicine resistance.The mean follow-up of the patients was 88.5 ± 61.9 months. Following the treatment with IL-1 antagonists; serum Amyloid A (SAA) averages (79.4 ± 35.3 mg/L) as well as the average number of hospitalizations per month due to FMF episodes (1.4 ± 0.5 times/month) decreased significantly (26.6 ± 25.9 mg/L and 0.1 ± 0.3 times/month) (p .001). Rates of death with a functional graft were 30% and 0% in group 1 and 2 (p = .086). Biopsy-proven AA amyloidosis recurrence in the allograft was observed in 11 of 19 (58%) and seven of nine (78%) patients in group 1 and 2, respectively. Interestingly, glomerular amyloid deposition was not present in the vast majority of biopsies. De novo vasculer amyloid deposition was observed during treatment.IL-1 antagonist drug and colchicine combination almost completely prevented acute FMF attacks in kidney transplant patients with colchicine resistance. However, amyloid accumulation did not cease during IL-1 antagonist drug treatment.
- Subjects :
- Drug
medicine.medical_specialty
media_common.quotation_subject
030230 surgery
Antibodies, Monoclonal, Humanized
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Humans
Colchicine
Serum amyloid A
Kidney transplantation
media_common
Transplantation
business.industry
Antagonist
Interleukin
medicine.disease
Kidney Transplantation
Familial Mediterranean Fever
Interleukin 1 Receptor Antagonist Protein
Pharmaceutical Preparations
chemistry
COLCHICINE RESISTANCE
030211 gastroenterology & hepatology
business
Interleukin-1
Subjects
Details
- ISSN :
- 13990012 and 09020063
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Clinical Transplantation
- Accession number :
- edsair.doi.dedup.....d3450191d55fd802a3653a75983d2e95